Identification of Essential Genes in Caenorhabditis elegans with Lethal Mutations Maintained by Genetic Balancers.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1720-5_19
Abstract: Genetic balancer systems, which allow effective capture and maintenance of lethal mutations stably, play an important role in identifying essential genes. Whole-genome sequencing (WGS) followed by bioinformatics analysis, combined with genetic mapping data analysis, allows… read more here.
Keywords: genes caenorhabditis; caenorhabditis elegans; essential genes; lethal mutations ... See more keywords
Radiobiological characteristics of descendant progeny of fish and amphibian cells that survive the initial ionizing radiation dose
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DOI: 10.1016/j.envres.2018.11.047
Abstract: Purpose To evaluate the development of delayed lethal mutations, the production of medium borne lethal bystander signals, and the acquirement of radiosensitive or radioresistant traits in distant descendant progeny of fish and amphibian cells surviving… read more here.
Keywords: delayed lethal; fish amphibian; amphibian cells; progeny ... See more keywords
Lethal mutations with fluctuating heterozygous effect: the lethal force of effective dominance
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DOI: 10.1038/s10038-020-0801-3
Abstract: The theory of population genetics leads to the expectation that in very large populations the frequencies of recessive lethal mutations are close to the square root of the mutation rate, corresponding to mutation-selection balance. There… read more here.
Keywords: heterozygous effect; dominance coefficient; effective dominance; dominance ... See more keywords
Screening and molecular characterization of lethal mutations of human homogentisate 1, 2 dioxigenase
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DOI: 10.1080/07391102.2020.1736158
Abstract: Abstract Alkaptonuria (AKU) is an autosomal recessive disorder, which is caused by a site-specific mutation(s) and thus, impaired the function of Homogentisate-1, 2-dioxygenase (HGD), an essential enzyme for the catabolism of phenylalanine and tyrosine. Among… read more here.
Keywords: molecular characterization; mutations human; disease; characterization lethal ... See more keywords