VRK1 Is a Synthetic–Lethal Target in VRK2-Deficient Glioblastoma
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Research"
DOI: 10.1158/0008-5472.can-21-4443
Abstract: A paralog synthetic–lethal interaction between VRK1 and VRK2 sensitizes VRK2-methylated glioblastoma to perturbation of VRK1 kinase activity, supporting VRK1 as a drug discovery target in this disease. read more here.
Keywords: synthetic lethal; glioblastoma; lethal target; vrk1 synthetic ... See more keywords
Abstract 3707: UXS1 is a synthetic lethal target in cancer
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-3707
Abstract: Studies presented here were conducted to validate UXS1 as a synthetic lethal target in UGDHhigh expressing cancer. In vitro and in vivo knockout studies were used to investigate the role of UXS1 in UGDH-high cancers.… read more here.
Keywords: synthetic lethal; knockout; lethal target; cancer ... See more keywords