Exploiting synthetic lethality to target BRCA1/2-deficient tumors: where we stand
Sign Up to like & getrecommendations! Published in 2021 at "Oncogene"
DOI: 10.1038/s41388-021-01744-2
Abstract: The principle of synthetic lethality, which refers to the loss of viability resulting from the disruption of two genes, which, individually, do not cause lethality, has become an attractive target approach due to the development… read more here.
Keywords: synthetic lethality; exploiting synthetic; lethality target; target brca1 ... See more keywords
Abstract PR18: Leveraging synthetic lethality to target convergent therapeutic resistance
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1538-8514.synthleth-pr18
Abstract: Our laboratory uses genomic and pharmacological methods to define the pathways of resistance to targeted anticancer therapies. Toward this end, we recently developed a technique in which engineered lentiviral cDNAs encoding activators of major oncogenic… read more here.
Keywords: synthetic lethality; lethality target; resistance; leveraging synthetic ... See more keywords