Complete dominant inheritance of intracellular leucine accumulation traits in polyploid yeasts
Sign Up to like & getrecommendations! Published in 2022 at "Yeast"
DOI: 10.1002/yea.3700
Abstract: The yeast Saccharomyces cerevisiae is widely used for ethanol production. In the production of alcoholic beverages, flavours are affected mainly by yeast metabolism in the fermentation process. To increase the contents of initial scented fruity… read more here.
Keywords: complete dominant; leucine accumulation; polyploid yeasts; intracellular leucine ... See more keywords
L-leucine stimulates glutamate dehydrogenase activity and glutamate synthesis by regulating mTORC1/SIRT4 pathway in pig liver
Sign Up to like & getrecommendations! Published in 2018 at "Animal Nutrition"
DOI: 10.1016/j.aninu.2017.12.002
Abstract: The liver is the most essential organ for the metabolism of ammonia, in where most of ammonia is removed by urea and glutamine synthesis. Regulated by leucine, glutamate dehydrogenase (GDH) catalyzes the reversible inter-conversion of… read more here.
Keywords: liver; leucine; activity; synthesis ... See more keywords
Leucine-induced localization of Leucyl-tRNA synthetase in lysosome membrane.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.09.008
Abstract: Leucyl-tRNA synthetase (LRS) plays major roles in providing leucine-tRNA and activating mechanistic target of rapamycin complex 1 (mTORC1) through intracellular leucine sensing. mTORC1 activated by amino acids affects the influence on physiology functions including cell… read more here.
Keywords: microscopy; leucine sensing; leucyl trna; trna synthetase ... See more keywords
Muscle‐specific deletion of SOCS3 does not reduce the anabolic response to leucine in a mouse model of acute inflammation
Sign Up to like & getrecommendations! Published in 2017 at "Cytokine"
DOI: 10.1016/j.cyto.2017.05.016
Abstract: HighlightsSOCS3 deletion in skeletal muscle does not alter LPS‐induced inflammation.SOCS3 does not mediate the anabolic response to leucine in skeletal muscle.Leucine augments the LPS‐induced expression of IL‐6 and STAT3 phosphorylation. Abstract Excessive inflammation reduces skeletal… read more here.
Keywords: socs3; response; muscle; deletion ... See more keywords
Effect of storage temperature on the stability of spray dried bacteriophage powders
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmaceutics and Biopharmaceutics"
DOI: 10.1016/j.ejpb.2018.02.033
Abstract: Graphical abstract Figure. No caption available. &NA; This study aimed to assess the robustness of using a spray drying approach and formulation design in producing inhalable phage powders. Two types of Pseudomonas phages, PEV2 (Podovirus)… read more here.
Keywords: storage; phage; formulation; leucine ... See more keywords
D‐leucine microparticles as an excipient to improve the aerosolization performances of dry powders for inhalation
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ejps.2019.01.018
Abstract: ABSTRACT The objective of the work was to produce a new excipient based on D‐leucine to improve the aerosolization properties of the poorly flowable micronized budesonide. The D‐leucine powders produced by a nano spray‐dryer were… read more here.
Keywords: dry powders; powders inhalation; micronized budesonide; improve aerosolization ... See more keywords
Leucine Enhances the Dispersibility of Trehalose-Containing Spray-Dried Powders on Exposure to a High-Humidity Environment.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2021.120561
Abstract: This study investigates the ability of various shell-forming excipients to preserve the dispersibility of dry powder dosage forms, e.g., nasally administered vaccines, upon exposure to a high-humidity environment. Trehalose combinations using leucine, pullulan, or trileucine… read more here.
Keywords: humidity environment; dispersibility; exposure high; high humidity ... See more keywords
Rapid sensing of l-leucine by human and murine hypothalamic neurons: Neurochemical and mechanistic insights
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Metabolism"
DOI: 10.1016/j.molmet.2018.01.021
Abstract: Objective Dietary proteins are sensed by hypothalamic neurons and strongly influence multiple aspects of metabolic health, including appetite, weight gain, and adiposity. However, little is known about the mechanisms by which hypothalamic neural circuits controlling… read more here.
Keywords: hypothalamic neurons; murine; rapid sensing; sensing leucine ... See more keywords
Synthesis and Characterization of a Leucine-Based Block Co-Polypeptide: The Effect of the Leucine Zipper on Self-Assembly.
Sign Up to like & getrecommendations! Published in 2020 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.0c00420
Abstract: The self-assembly behavior of an ABC triblock copolypeptide consisting of poly(ethylene oxide-b-(leucine-s-valine)-b-lysine) (PEO-PLV-PK) was examined via dynamic light scattering in dilute aqueous solution. Leucine is a hydrophobic, α-helix forming polypeptide that exhibits a "zipper effect"… read more here.
Keywords: leucine zipper; self assembly; effect; leucine ... See more keywords
Biomolecular Fishing: Design, Green Synthesis, and Performance of l-Leucine-Molecularly Imprinted Polymers
Sign Up to like & getrecommendations! Published in 2023 at "ACS Omega"
DOI: 10.1021/acsomega.2c05714
Abstract: Biopurification is a challenging and growing market. Despite great efforts in the past years, current purification strategies still lack specificity, efficiency, and cost-effectiveness. The development of more sustainable functional materials and processes needs to address… read more here.
Keywords: biomolecular fishing; imprinted polymers; molecularly imprinted; design ... See more keywords
Effect of grinding process of steam-rolled barley grain on plasma glucose and leucine kinetics and protein synthesis in sheep
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Applied Animal Research"
DOI: 10.1080/09712119.2017.1383259
Abstract: ABSTRACT An isotope dilution method of [U-13C]glucose and [l-13C]leucine was simultaneously conducted to determine the effect of grinding process of steam-rolled barley grain on rates of plasma glucose and leucine turnover and whole-body protein synthesis… read more here.
Keywords: rolled barley; barley; steam rolled; leucine ... See more keywords