Antiepileptic drug therapy in autoimmune epilepsy associated with antibodies targeting the leucine‐rich glioma‐inactivated protein 1
Sign Up to like & getrecommendations! Published in 2018 at "Epilepsia Open"
DOI: 10.1002/epi4.12226
Abstract: To characterize seizure semiology and the utility of antiepileptic drug (AED) therapy in leucine‐rich glioma inactivated‐1 ( LGI1‐Ab) autoimmune epilepsy (AE). read more here.
Keywords: leucine rich; autoimmune epilepsy; glioma inactivated; rich glioma ... See more keywords
Leucine‐Rich Amelogenin Peptide (LRAP) Uptake by Cementoblast Requires Flotillin‐1 Mediated Endocytosis
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.25453
Abstract: Basic, pre‐clinical, and clinical studies have documented the potential of amelogenin, and its variants, to affect cell response and tissue regeneration. However, the mechanisms are unclear. Thus, the aim of the present study was to… read more here.
Keywords: rich amelogenin; leucine rich; lrap uptake; endocytosis ... See more keywords
A Case of Bilaterally Synchronized Faciobrachial Dystonic Seizures in Anti‐Leucine‐Rich Glioma Inactivated‐1 Encephalitis
Sign Up to like & getrecommendations! Published in 2020 at "Movement Disorders Clinical Practice"
DOI: 10.1002/mdc3.12934
Abstract: Faciobrachial dystonic seizures (FBDS), a hallmark of autoimmune encephalitis with leucine-rich glioma inactivated-1 (LGI1) antibodies (anti-LGI1 encephalitis) usually present as brief dystonic contraction of unilateral face and ipsilateral arm lasting less than 3 seconds. Here,… read more here.
Keywords: faciobrachial dystonic; bilaterally synchronized; leucine rich; fbds ... See more keywords
LRRK2‐mediated Rab10 phosphorylation in immune cells from Parkinson's disease patients
Sign Up to like & getrecommendations! Published in 2019 at "Movement Disorders"
DOI: 10.1002/mds.27601
Abstract: Leucine‐rich repeat kinase 2 is a potential therapeutic target for the treatment of Parkinson's disease, and clinical trials of leucine‐rich repeat kinase 2 inhibitors are in development. The objective of this study was to evaluate… read more here.
Keywords: parkinson disease; rich repeat; repeat kinase; leucine rich ... See more keywords
Genetic analysis of nucleotide-binding leucine-rich repeat (NLR) receptors in multiple sclerosis
Sign Up to like & getrecommendations! Published in 2020 at "Immunogenetics"
DOI: 10.1007/s00251-020-01170-w
Abstract: Genetic and functional analyses of the inflammasome suggest a role for this multiprotein complex in the biological mechanisms leading to the onset and progression of multiple sclerosis (MS). Nucleotide-binding, leucine-rich repeat (NLR) receptors trigger the… read more here.
Keywords: nlr receptors; multiple sclerosis; rich repeat; leucine rich ... See more keywords
Isolation, production, and analysis of small leucine-rich proteoglycans in bone.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in cell biology"
DOI: 10.1016/bs.mcb.2017.08.016
Abstract: Small leucine-rich proteoglycans (SLRPs) are a unique class of proteins that exist in the extracellular matrix, playing key roles in cell proliferation and function. In bone, SLRPs such as biglycan and decorin affect osteogenesis and… read more here.
Keywords: production; rich proteoglycans; leucine rich; small leucine ... See more keywords
The leucine-rich repeat domain of human peroxidasin 1 promotes binding to laminin in basement membranes.
Sign Up to like & getrecommendations! Published in 2020 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2020.108443
Abstract: Human peroxidasin 1 (PXDN) is a homotrimeric multidomain heme peroxidase and essential for tissue development and architecture. It has a biosynthetic function and catalyses the hypobromous acid-mediated formation of specific covalent sulfilimine (SN) bonds, which… read more here.
Keywords: leucine rich; repeat domain; human peroxidasin; basement membranes ... See more keywords
The heterozygous R1441C mutation of leucine-rich repeat kinase 2 gene in a Chinese patient with Parkinson disease: A five-year follow-up and literatures review
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the Neurological Sciences"
DOI: 10.1016/j.jns.2016.12.009
Abstract: BACKGROUND Leucine-rich repeat kinase 2 gene (LRRK2) was recognized associated with both familial and sporadic Parkinson Disease (PD). Seven missense mutations (G2019S, R1441C, R1441G, R1441H, Y1699C, I2020T, N1437H) of it have been confirmed disease- causing.… read more here.
Keywords: kinase gene; leucine rich; disease; repeat kinase ... See more keywords
Genome-wide identification, characterization, and expression analysis of nucleotide-binding leucine-rich repeats gene family under environmental stresses in tea (Camellia sinensis).
Sign Up to like & getrecommendations! Published in 2019 at "Genomics"
DOI: 10.1016/j.ygeno.2019.08.004
Abstract: Plants often use nucleotide-binding leucine-rich repeats (NLRs) to recognize specific virulence proteins and activate the hypersensitive response thereby defending against invaders. However, data on NLRs and the resistance mechanism of NLR protein mediation in tea… read more here.
Keywords: sinensis; leucine rich; nucleotide binding; analysis ... See more keywords
The Development and Design Strategy of Leucine-Rich Repeat Kinase 2 Inhibitors: Promising Therapeutic Agents for Parkinson's Disease.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01552
Abstract: Parkinson's disease (PD) is a progressive neurodegenerative disorder affecting millions of people worldwide. Mutations in the gene encoding leucine-rich repeat kinase 2 (LRRK2) are the most common genetic risk factor for PD. Elevated LRRK2 kinase… read more here.
Keywords: repeat kinase; leucine rich; parkinson disease; kinase ... See more keywords
Design of Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using a Crystallographic Surrogate Derived from Checkpoint Kinase 1 (CHK1).
Sign Up to like & getrecommendations! Published in 2017 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.7b01186
Abstract: Mutations in leucine-rich repeat kinase 2 (LRRK2), such as G2019S, are associated with an increased risk of developing Parkinson's disease. Surrogates for the LRRK2 kinase domain based on checkpoint kinase 1 (CHK1) mutants were designed,… read more here.
Keywords: chk1; leucine rich; kinase; lrrk2 inhibitors ... See more keywords