Leucovorin (folinic acid) rescue for high‐dose methotrexate: A review
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Pharmacy and Therapeutics"
DOI: 10.1111/jcpt.13739
Abstract: High‐dose methotrexate (HDMTX) is active against various malignancies; it possesses serious toxicities and is associated with patient characteristics, dosage regimens, comedications, and physiological status. There are many strategies to overcome HDMTX‐induced toxicities, such as hydration,… read more here.
Keywords: rescue; dose methotrexate; leucovorin; high dose ... See more keywords
Changes in intracellular folate metabolism during high-dose methotrexate and Leucovorin rescue therapy in children with acute lymphoblastic leukemia
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DOI: 10.1371/journal.pone.0221591
Abstract: Background Methotrexate (MTX) is an important anti-folate agent in pediatric acute lymphoblastic leukemia (ALL) treatment. Folinic acid rescue therapy (Leucovorin) is administered after MTX to reduce toxicity. Previous studies hypothesized that Leucovorin could ‘rescue’ both… read more here.
Keywords: folate; folate levels; leucovorin; intracellular folate ... See more keywords