Antitumour effects of selected plant polyphenols, gallic acid and ellagic acid, on sensitive and multidrug‐resistant leukaemia HL60 cells
Sign Up to like & getrecommendations! Published in 2019 at "Phytotherapy Research"
DOI: 10.1002/ptr.6317
Abstract: The aim of this study was to examine the antitumour effects of plant phenolic acids, gallic acid (GA) and ellagic acid (EA), on human promyelocytic leukaemia sensitive HL60 cell line and its resistant sublines exhibiting… read more here.
Keywords: gallic acid; antitumour effects; hl60 cells; acid ellagic ... See more keywords
A rare cause of respiratory failure in acute myeloid leukaemia patient
Sign Up to like & getrecommendations! Published in 2020 at "Annals of Hematology"
DOI: 10.1007/s00277-020-04172-6
Abstract: Dear Editor, A 24-year-old Moroccan woman, from a rural area, presented with a 2-month history of progressive fatigue, dyspnea and abdominal pain. Physical examination was normal. Her past history included diabetes. Laboratory investigations showed a… read more here.
Keywords: myeloid leukaemia; acute myeloid; leukaemia; respiratory failure ... See more keywords
Overexpression of the giant FAT1 cadherin gene and its prognostic significance in de novo acute leukaemia patients
Sign Up to like & getrecommendations! Published in 2017 at "Comparative Clinical Pathology"
DOI: 10.1007/s00580-017-2409-3
Abstract: FAT1 is a type 1 transmembrane protein belonging to the cadherin superfamily. Many reports showed either overexpression of FAT1 gene or its loss in solid cancers. Limited studies evaluated its importance in leukemogenesis. Real-time quantitative… read more here.
Keywords: adult aml; fat1; overexpression giant; leukaemia ... See more keywords
Acute Myeloid Leukaemia in Its Niche: the Bone Marrow Microenvironment in Acute Myeloid Leukaemia
Sign Up to like & getrecommendations! Published in 2020 at "Current Oncology Reports"
DOI: 10.1007/s11912-020-0885-0
Abstract: Purpose of Review Acute myeloid leukaemia (AML) is a heterogeneous malignancy for which treatment options remain suboptimal. It is clear that a greater understanding of the biology of the AML niche will enable new therapeutic… read more here.
Keywords: bone marrow; leukaemia; myeloid leukaemia; acute myeloid ... See more keywords
Targeting ADP-ribosylation by PARP inhibitors in acute myeloid leukaemia and related disorders.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2019.04.019
Abstract: Acute myeloid leukaemia (AML) is a highly heterogeneous disease characterized by uncontrolled proliferation, block in myeloid differentiation and recurrent genetic abnormalities. In the search of new effective therapies, identification of synthetic lethal partners of AML… read more here.
Keywords: adp ribosylation; targeting adp; myeloid leukaemia; ribosylation parp ... See more keywords
Spatial clustering of childhood leukaemia with the integration of the Paediatric Environmental History
Sign Up to like & getrecommendations! Published in 2017 at "Environmental Research"
DOI: 10.1016/j.envres.2017.04.019
Abstract: Background: Leukaemia remains the most common type of paediatric cancer and its aetiology remains unknown, but considered to be multifactorial. It is suggested that the initiation in utero by relevant exposures and/or inherited genetic variants… read more here.
Keywords: childhood leukaemia; paediatric environmental; childhood; environmental history ... See more keywords
Feline Leukaemia Virus Associated with Leukaemia in Cats in Santa Catarina, Brazil.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of comparative pathology"
DOI: 10.1016/j.jcpa.2019.05.002
Abstract: Leukaemia is a haemopoietic neoplasm originating from myeloid or lymphoid precursors in the bone marrow and may be either acute or chronic. These tumours are rare, but occur more frequently in cats because of an… read more here.
Keywords: felv fiv; leukaemia virus; feline leukaemia; leukaemia ... See more keywords
Measurable residual disease testing in acute myeloid leukaemia
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DOI: 10.1038/leu.2017.113
Abstract: There is considerable interest in developing techniques to detect and/or quantify remaining leukaemia cells termed measurable or, less precisely, minimal residual disease (MRD) in persons with acute myeloid leukaemia (AML) in complete remission defined by… read more here.
Keywords: mrd test; residual disease; leukaemia; relapse ... See more keywords
BCAT1 restricts αKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation
Sign Up to like & getrecommendations! Published in 2017 at "Nature"
DOI: 10.1038/nature24294
Abstract: The branched-chain amino acid (BCAA) pathway and high levels of BCAA transaminase 1 (BCAT1) have recently been associated with aggressiveness in several cancer entities. However, the mechanistic role of BCAT1 in this process remains largely… read more here.
Keywords: idhmut; bcat1; dna hypermethylation; stem ... See more keywords
Diagnostic and therapeutic pitfalls in NPM1-mutated AML: notes from the field
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DOI: 10.1038/s41375-021-01222-4
Abstract: Mutations of Nucleophosmin (NPM1) are the most common genetic abnormalities in adult acute myeloid leukaemia (AML), accounting for about 30% of cases. NPM1-mutated AML has been recognized as distinct entity in the 2017 World Health… read more here.
Keywords: diagnostic therapeutic; mutated aml; therapeutic pitfalls; cases npm1 ... See more keywords
Proliferation dynamics of acute myeloid leukaemia and haematopoietic progenitors competing for bone marrow space
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DOI: 10.1038/s41467-017-02376-5
Abstract: Leukaemia progressively invades bone marrow (BM), outcompeting healthy haematopoiesis by mechanisms that are not fully understood. Combining cell number measurements with a short-timescale dual pulse labelling method, we simultaneously determine the proliferation dynamics of primitive haematopoietic… read more here.
Keywords: leukaemia; proliferation dynamics; bone marrow;