Alginate foam-based three-dimensional culture to investigate drug sensitivity in primary leukaemia cells
Sign Up to like & getrecommendations! Published in 2018 at "Journal of The Royal Society Interface"
DOI: 10.1098/rsif.2017.0928
Abstract: The development of assays for evaluating the sensitivity of leukaemia cells to anti-cancer agents is becoming an important aspect of personalized medicine. Conventional cell cultures lack the three-dimensional (3D) structure of the bone marrow (BM),… read more here.
Keywords: three dimensional; leukaemia cells; sensitivity; foam based ... See more keywords
Role of CXCR4 in the progression and therapy of acute leukaemia
Sign Up to like & getrecommendations! Published in 2021 at "Cell Proliferation"
DOI: 10.1111/cpr.13076
Abstract: CXCR4 is expressed on leukaemia cells and haematopoietic stem cells (HSCs), and its ligand stromal‐derived factor 1 (SDF‐1) is produced abundantly by stromal cells in the bone marrow (BM). The SDF‐1/CXCR4 axis plays important roles… read more here.
Keywords: acute leukaemia; leukaemia cells; cxcr4 progression; leukaemia ... See more keywords
The combination of FLT3 and SYK kinase inhibitors is toxic to leukaemia cells with CBL mutations
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.14820
Abstract: Mutations in the E3 ubiquitin ligase CBL, found in several myeloid neoplasms, lead to decreased ubiquitin ligase activity. In murine systems, these mutations are associated with cytokine‐independent proliferation, thought to result from the activation of… read more here.
Keywords: mutant cbl; leukaemia cells; kinase; inhibition ... See more keywords
p53 as a unique target of action of cisplatin in acute leukaemia cells
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.17502
Abstract: Acute promyelocytic leukaemia (APL) occurs in approximately 10% of acute myeloid leukaemia patients. Arsenic trioxide (ATO) has been for APL chemotherapy, but recently several ATO‐resistant cases have been reported worldwide. Cisplatin (CDDP) enhances the toxicity… read more here.
Keywords: leukaemia; apl; action; leukaemia cells ... See more keywords
MYD88 Inhibitor ST2825 Suppresses the Growth of Lymphoma and Leukaemia Cells.
Sign Up to like & getrecommendations! Published in 2017 at "Anticancer research"
DOI: 10.21873/anticanres.12070
Abstract: BACKGROUND/AIM Myeloid differentiation primary response gene 88 (MYD88), which activates the nuclear factor kappa B (NF-κB) pathway, is important for the growth of lymphoma and leukaemia cells. In this study, we investigated the effects of… read more here.
Keywords: lymphoma leukaemia; leukaemia cells; st2825; growth lymphoma ... See more keywords
Identification of uPAR Variants Acting as ceRNAs in Leukaemia Cells
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14081980
Abstract: Simple Summary The urokinase (uPA) receptor (uPAR) concentrates proteolytic activities on the cell surface and is an adhesion receptor for vitronectin. Urokinase/Vitronectin binding to uPAR activates intracellular signals promoting cell adhesion, migration, proliferation and survival.… read more here.
Keywords: leukaemia; pro tumoral; upar mrna; upar variants ... See more keywords
The Role of Autophagy and Apoptosis in the Combined Action of Plasma-Treated Saline, Doxorubicin, and Medroxyprogesterone Acetate on K562 Myeloid Leukaemia Cells
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24065100
Abstract: The anti-cancer properties of plasma-treated solutions (PTS) and their interaction with drugs are one of the most popular topics in modern plasma medicine. Our research involved comparing the effects of four physiological saline solutions (0.9%… read more here.
Keywords: medroxyprogesterone acetate; k562 myeloid; plasma treated; myeloid leukaemia ... See more keywords
Glycometabolic adaptation mediates the insensitivity of drug-resistant K562/ADM leukaemia cells to adriamycin via the AKT-mTOR/c-Myc signalling pathway.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular medicine reports"
DOI: 10.3892/mmr.2017.6189
Abstract: In human leukaemia, resistance to chemotherapy leads to treatment ineffectiveness or failure. Previous studies have indicated that cancers with increased levels of aerobic glycolysis are insensitive to numerous forms of chemotherapy and respond poorly to… read more here.
Keywords: leukaemia cells; glycolysis; k562 adm; mtor ... See more keywords
Epigenetic therapy with chidamide alone or combined with 5-azacitidine exerts antitumour effects on acute myeloid leukaemia cells in vitro
Sign Up to like & getrecommendations! Published in 2022 at "Oncology Reports"
DOI: 10.3892/or.2022.8277
Abstract: Chidamide, a selective histone deacetylase inhibitor, has antitumour effects. 5-azacitidine (5-AZA), a hypomethylating agent, is effective in treating acute myeloid leukaemia (AML) and myelodysplastic syndrome. However, to the best of our knowledge, the effect of… read more here.
Keywords: chidamide alone; chidamide; antitumour effects; acute myeloid ... See more keywords