Dissecting the early steps of MLL induced leukaemogenic transformation using a mouse model of AML
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DOI: 10.1038/s41467-020-15220-0
Abstract: Leukaemogenic mutations commonly disrupt cellular differentiation and/or enhance proliferation, thus perturbing the regulatory programs that control self-renewal and differentiation of stem and progenitor cells. Translocations involving the Mll1 ( Kmt2a ) gene generate powerful oncogenic… read more here.
Keywords: model; mouse model; leukaemogenic transformation; mll enl ... See more keywords