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   Articles with "leukapheresis" as a keyword



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Autologous cryopreserved leukapheresis cellular material for chimeric antigen receptor-T cell manufacture.

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recommendations! Published in 2019 at "Cytotherapy"

DOI: 10.1016/j.jcyt.2019.10.005

Abstract: Tisagenlecleucel, a CD19-specific autologous chimeric antigen receptor (CAR)-T cell therapy, is efficacious for the treatment of relapsed/refractory B-cell precursor acute lymphoblastic leukemia and diffuse large B-cell lymphoma. The tisagenlecleucel manufacturing process was initially developed in… read more here.

Keywords: leukapheresis; cryopreserved leukapheresis; process; material ... See more keywords
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Automated leukapheresis cryopreparation using fully-defined synthetic solutions

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recommendations! Published in 2020 at "Cytotherapy"

DOI: 10.1016/j.jcyt.2020.03.340

Abstract: Background & Aim Leukapheresis products are commonly used as source material for cell and gene therapy products. To avoid risks associated with shipping/storing fresh products and to optimize manufacturing logistics, this starting material may be… read more here.

Keywords: plasma; leukapheresis; using fully; leukapheresis cryopreparation ... See more keywords
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PDCT-10. FEASIBILITY OF LEUKAPHERESIS FOR HARVESTING MONOCYTES AND GENERATING AUTOLOGOUS DENDRITIC CELL VACCINES IN CHILDREN WITH MALIGNANT BRAIN TUMORS

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recommendations! Published in 2019 at "Neuro-Oncology"

DOI: 10.1093/neuonc/noz175.772

Abstract: Recurrent medulloblastoma and malignant glioma are virtually incurable. In children, these tumors are often disseminated or occur in deep midline structures that preclude surgery and are not amenable to highly inflammatory treatments. Active immunization is… read more here.

Keywords: leukapheresis; cell vaccines; dendritic cells; vaccines children ... See more keywords
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A comparison of four leukapheresis methods to harvest an optimal dose of CD34+ cells: A single center experience

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recommendations! Published in 2022 at "European Journal of Haematology"

DOI: 10.1111/ejh.13856

Abstract: Chemokine receptor CXCR4 antagonist plerixafor (Px) as well as high volume (HV) leukapheresis have been shown to reduce hematopoietic stem progenitor cell (HSPC) mobilization failure rates. However, no direct comparisons of such methods currently exists. read more here.

Keywords: methods harvest; leukapheresis; four leukapheresis; harvest optimal ... See more keywords
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Impact of mobilization regimen on multiday collection of peripheral blood CD34+ cells by large volume leukapheresis

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recommendations! Published in 2022 at "Transfusion"

DOI: 10.1111/trf.16842

Abstract: The collection yield of hematopoietic progenitors cell (HPC) by leukapheresis is critical for a successful transplantation, which often requires multiday collections to achieve the collection goal. read more here.

Keywords: mobilization regimen; impact mobilization; leukapheresis; regimen multiday ... See more keywords
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Leukapheresis and Hyperleukocytosis, Past and Future

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recommendations! Published in 2021 at "International Journal of General Medicine"

DOI: 10.2147/ijgm.s321787

Abstract: Abstract Hyperleukocytosis is a hematologic crisis caused by excessive proliferation of leukemic cells and has a relatively high early mortality due to a series of severe complications. Therefore, prompt and effective intervention is required. Leukapheresis… read more here.

Keywords: medicine; past future; hyperleukocytosis past; leukapheresis hyperleukocytosis ... See more keywords
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Comparison of Neutrophil Function in Granulocyte Concentrates From Prednisone- and G-CSF-Treated Donors: Effect of Stimulant, Leukapheresis and Storage

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recommendations! Published in 2022 at "Frontiers in Medicine"

DOI: 10.3389/fmed.2022.839475

Abstract: Transfusion of granulocyte concentrates (GC) is an alternative therapy for neutropenic patients with life-threatening infections. While neutrophils are the main source of antimicrobial activity, only neutrophil numbers are used to certify GCs. The objective of… read more here.

Keywords: granulocyte concentrates; prednisone csf; csf; leukapheresis ... See more keywords