Report of the relapsed/refractory cohort of SWOG S0919: A phase 2 study of idarubicin and cytarabine in combination with pravastatin for acute myelogenous leukemia (AML).
Sign Up to like & getrecommendations! Published in 2018 at "Leukemia research"
DOI: 10.1016/j.leukres.2018.01.021
Abstract: Inhibition of cholesterol synthesis and uptake sensitizes acute myeloid leukemia (AML) blasts to chemotherapy. A Phase 2 study of high dose pravastatin given in combination with idarubicin and cytarabine demonstrated an impressive response rate [75%… read more here.
Keywords: poor risk; risk; leukemia aml; study ... See more keywords
Unveiling the Genetic and Clinical Differences of Acute Myeloid Leukemia (AML) in Obese Patients
Sign Up to like & getrecommendations! Published in 2024 at "European Journal of Haematology"
DOI: 10.1111/ejh.14338
Abstract: The molecular architecture of acute myeloid leukemia (AML) is heterogeneous. Obesity has been identified as a risk factor for the development of AML. There remains a scarcity of data elucidating the specific genetic profile of… read more here.
Keywords: aml obese; acute myeloid; obese patients; leukemia aml ... See more keywords
Abstract 6381: SAMHD1high macrophages drive resistance to cytarabine in acute myeloid leukemia (AML) by pyrimidine metabolite deoxycytidine (dC)
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-6381
Abstract: Increasing evidence highlights macrophages as critical players in tumorigenesis and therapeutic resistance in both solid and liquid tumors. While macrophages in solid cancers are largely pro-tumor and associated with poor prognosis, their contribution to acute… read more here.
Keywords: resistance; acute myeloid; pyrimidine metabolite; leukemia ... See more keywords
Tunneling nanotube (TNT) formation is downregulated by cytarabine and NF-κB inhibition in acute myeloid leukemia (AML)
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.13853
Abstract: Acute myeloid leukemia (AML) is a bone marrow derived blood cancer where intercellular communication in the leukemic bone marrow participates in disease development, progression and chemoresistance. Tunneling nanotubes (TNTs) are intercellular communication structures involved in… read more here.
Keywords: myeloid leukemia; leukemia aml; formation; tnt formation ... See more keywords
Profile of Glasdegib for the Treatment of Newly Diagnosed Acute Myeloid Leukemia (AML): Evidence to Date
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Management and Research"
DOI: 10.2147/cmar.s195723
Abstract: Abstract Acute myeloid leukemia (AML) is an aggressive hematologic malignancy primarily affecting older adults. Historically, the highest rates of response have been achieved with intensive induction chemotherapy; however, a significant portion of older or unfit… read more here.
Keywords: myeloid leukemia; leukemia aml; newly diagnosed; acute myeloid ... See more keywords
Bronchial myeloid sarcoma secondary to acute monoblastic leukemia (AML-M5): a rare Case Report
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2025.1703260
Abstract: Bronchial myeloid sarcoma (BMS) is an extramedullary rare extramedullary manifestation of acute myeloid leukemia (AML), with only eight cases previously reported worldwide. In this report, we present the ninth documented case of BMS occurring in… read more here.
Keywords: bronchial myeloid; leukemia; case; leukemia aml ... See more keywords
Descriptive and Functional Genomics in Acute Myeloid Leukemia (AML): Paving the Road for a Cure
Sign Up to like & getrecommendations! Published in 2021 at "Cancers"
DOI: 10.3390/cancers13040748
Abstract: Simple Summary Acute myeloid leukemia (AML) accounts for 7.6% of hematopoietic malignancies with a long-term survival of less than 20%. Better understanding its physiopathology and finding new treatments remain important issues. In the current review,… read more here.
Keywords: myeloid leukemia; functional genomics; leukemia aml; acute myeloid ... See more keywords
A Curious Novel Combination of Nucleophosmin (NPM1) Gene Mutations Leading to Aberrant Cytoplasmic Dislocation of NPM1 in Acute Myeloid Leukemia (AML)
Sign Up to like & getrecommendations! Published in 2021 at "Genes"
DOI: 10.3390/genes12091426
Abstract: Nucleophosmin (NPM1) mutations occurring in acute myeloid leukemia (AML) (about 50 so far identified) cluster almost exclusively in exon 12 and lead to common changes at the NPM1 mutants C-terminus, i.e., loss of tryptophans 288… read more here.
Keywords: myeloid leukemia; leukemia aml; acute myeloid; nucleophosmin npm1 ... See more keywords
Advances in DNA/RNA Sequencing and Their Applications in Acute Myeloid Leukemia (AML)
Sign Up to like & getrecommendations! Published in 2024 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms26010071
Abstract: Acute myeloid leukemia (AML) is an aggressive malignancy that poses significant challenges due to high rates of relapse and resistance to treatment, particularly in older populations. While therapeutic advances have been made, survival outcomes remain… read more here.
Keywords: dna rna; acute myeloid; rna sequencing; leukemia aml ... See more keywords
A Rare Cytogenetic Presentation of Acute Myeloid Leukemia (AML-M2) Mimicking Acute Promyelocytic Leukemia.
Sign Up to like & getrecommendations! Published in 2025 at "Clinical laboratory"
DOI: 10.7754/clin.lab.2024.240839
Abstract: BACKGROUND Acute myeloid leukemia (AML) with the t(8;21)(q22;q22) mutation, which produces the AML1/ETO fusion gene on chromosome 8q22, is a specific subtype of AML categorized as AML t(8;21) in the WHO classification and AML-M2 in… read more here.
Keywords: leukemia aml; leukemia; myeloid leukemia; acute myeloid ... See more keywords