Leukemia‐associated transcription factor mllt3 is important for primitive erythroid development in zebrafish embryogenesis
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DOI: 10.1002/dvdy.477
Abstract: MLLT3 (AF9) is a nuclear transcription factor crucial for hematopoietic stem cell and progenitor cell maintenance, but its role during embryonic hematopoiesis remains uncertain. Here, we examine the role of mllt3 in developmental hematopoiesis during… read more here.
Keywords: embryogenesis; leukemia associated; transcription; associated transcription ... See more keywords
Knockdown of let-7b in leukemia associated macrophages inhibit acute myeloid leukemia progression.
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DOI: 10.1002/hon.3120
Abstract: Macrophages, critical components of bone marrow microenvironment, are reported to be remodeled into leukemia-associated macrophages (LAMs) in leukemic microenvironment where they contribute to leukemia development, characterized as M2 macrophages with pro-tumor effects. However, how leukemic… read more here.
Keywords: myeloid leukemia; leukemia associated; aml patients; leukemia ... See more keywords
Prevalence and dynamics of clonal hematopoiesis caused by leukemia-associated mutations in elderly individuals without hematologic disorders
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DOI: 10.1038/s41375-020-0869-y
Abstract: Clonal hematopoiesis is frequently observed in elderly people. To investigate the prevalence and dynamics of genetic alterations among healthy elderly individuals, a cohort of 50 people >80 years was genotyped for commonly mutated leukemia-associated genes… read more here.
Keywords: leukemia associated; clonal hematopoiesis; elderly individuals; associated mutations ... See more keywords
Computational modeling and confirmation of leukemia-associated minor histocompatibility antigens.
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DOI: 10.1182/bloodadvances.2018022475
Abstract: T-cell responses to minor histocompatibility antigens (mHAs) mediate both antitumor immunity (graft-versus-leukemia [GVL]) and graft-versus-host disease (GVHD) in allogeneic stem cell transplant. Identifying mHAs with high allele frequency, tight binding affinity to common HLA molecules,… read more here.
Keywords: leukemia associated; histocompatibility antigens; antigen; minor histocompatibility ... See more keywords