Ormeloxifene, a nonsteroidal antifertility drug promotes megakaryocyte differentiation in leukemia cell line K562.
Sign Up to like & getrecommendations! Published in 2023 at "Cell biology international"
DOI: 10.1002/cbin.12017
Abstract: Ormeloxifene (ORM) (3,4-trans-2,2-dimethyl-3-phenyl-4-p-(β-pyrrolidinoethoxy) phenyl-7-methoxychroman), world's first nonsteroidal selective estrogen receptor modulator approved for contraception in India has been shown to have potential anticancer activities. Here, we show that ORM can induce megakaryocyte and myeloid (granulocytic) but not… read more here.
Keywords: leukemia cell; megakaryocytic differentiation; cell line; orm ... See more keywords
Evaluating Antigen-Specific IgE Using the Rat Basophil Leukemia Cell (RBL) Assay.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8549-4_22
Abstract: Allergic diseases (atopy) include asthma, allergic rhinitis, conjunctivitis, and allergic sinusitis. It is estimated that up to 90% of asthmatics are atopic and have an allergy trigger for asthmatic episodes. In order to assess the… read more here.
Keywords: leukemia cell; basophil leukemia; rbl assay; antigen ... See more keywords
A role for dystroglycan in the pathophysiology of acute leukemic cells
Sign Up to like & getrecommendations! Published in 2017 at "Life Sciences"
DOI: 10.1016/j.lfs.2017.06.004
Abstract: Aims: Previous reports have demonstrated that alterations or reduced expression of Dystroglycan (Dg) complex (&agr;Dg and &bgr;Dg subunits) are related to progression and severity of neoplastic solid tissues. Therefore we determined the expression pattern and… read more here.
Keywords: leukemia cell; cell lines; pathophysiology; expression ... See more keywords
Restoring leukemia cell function from the inside out.
Sign Up to like & getrecommendations! Published in 2017 at "Blood"
DOI: 10.1182/blood-2017-04-776344
Abstract: In this issue of Blood , Garzon et al 1 and Kuruvilla et al 2 report on the results of phase 1 dose-escalation studies of selinexor in patients with acute myeloid leukemia (AML) and different… read more here.
Keywords: leukemia cell; function inside; cell function; restoring leukemia ... See more keywords
Site-specific methylation of 18S ribosomal RNA by SNORD42A is required for Acute Myeloid Leukemia cell proliferation.
Sign Up to like & getrecommendations! Published in 2020 at "Blood"
DOI: 10.1182/blood.2019004121
Abstract: Non-coding RNAs including small nucleolar RNAs (snoRNAs) play important roles in leukemogenesis but the relevant mechanisms remain incompletely understood. We performed snoRNA focused CRISPR-Cas9 knockout library screenings which targeted the entire snoRNAnome and corresponding host… read more here.
Keywords: methylation; leukemia cell; snord42a; proliferation ... See more keywords
Pinostrobin induces acute leukemia cell apoptosis via the regulation of miR-410-5p and SFRP5.
Sign Up to like & getrecommendations! Published in 2023 at "Life sciences"
DOI: 10.2139/ssrn.4379242
Abstract: AIMS This study attempted to explore the mechanisms involved in pinostrobin (PN)-mediated acute leukemia cell apoptosis regulated by miR-410-5p. MATERIAL AND METHODS NB4 and MOLT-4 cells were cultured and treated with PN at the IC50… read more here.
Keywords: mir 410; acute leukemia; leukemia cell; apoptosis ... See more keywords
Potentiation of Differentiation and Apoptosis in a Human Promyelocytic Leukemia Cell Line by Garlic Essential Oil and Its Organosulfur Compounds
Sign Up to like & getrecommendations! Published in 2020 at "AntiCancer Research"
DOI: 10.21873/anticanres.14655
Abstract: Background/Aim: The clinical course of acute leukemia is complicated, and it is often necessary to combine or change treatment methods due to the rapid increase and spread of malignant cells. In this study, the potential… read more here.
Keywords: essential oil; leukemia cell; apoptosis; garlic essential ... See more keywords
Systematic In Vitro Evaluation of a Library of Approved and Pharmacologically Active Compounds for the Identification of Novel Candidate Drugs for KMT2A-Rearranged Leukemia
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2021.779859
Abstract: Patients whose leukemias harbor a rearrangement of the Mixed Lineage Leukemia (MLL/KMT2A) gene have a poor prognosis, especially when the disease strikes in infants. The poor clinical outcome linked to this aggressive disease and the… read more here.
Keywords: leukemia cell; novel candidate; leukemia; kmt2a leukemia ... See more keywords
Bacillamide F, Extracted from Marine Bacillus atrophaeus C89, Preliminary Effects on Leukemia Cell Lines
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DOI: 10.3390/biology11121712
Abstract: Simple Summary Bacillamides are important bioactive natural compounds. This paper depicts for the first time a study of a novel thiazole alkaloid compound bacillamide F that was isolated from the marine Bacillus atrophaeus C89. Bacillamide… read more here.
Keywords: cell; marine bacillus; leukemia cell; bacillus atrophaeus ... See more keywords
Shuterin Enhances the Cytotoxicity of the Natural Killer Leukemia Cell Line KHYG-1 by Increasing the Expression Levels of Granzyme B and IFN-γ through the MAPK and Ras/Raf Signaling Pathways
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232112816
Abstract: Natural killer (NK) cell therapy is an emerging tool for cancer immunotherapy. NK cells are isolated from peripheral blood, and their number and activity are limited. Therefore, primary NK cells should be expanded substantially, and… read more here.
Keywords: cell; leukemia cell; cytotoxicity; natural killer ... See more keywords
A Novel Protocol for the Synthesis of 1,2,4-Oxadiazoles Active against Trypanosomatids and Drug-Resistant Leukemia Cell Lines
Sign Up to like & getrecommendations! Published in 2022 at "Tropical Medicine and Infectious Disease"
DOI: 10.3390/tropicalmed7120403
Abstract: Cancer and parasitic diseases, such as leishmaniasis and Chagas disease, share similarities that allow the co-development of new antiproliferative agents as a strategy to quickly track the discovery of new drugs. This strategy is especially… read more here.
Keywords: leukemia cell; synthesis; drug resistant; cell lines ... See more keywords