Small molecular modulators of JMJD1C preferentially inhibit growth of leukemia cells
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Cancer"
DOI: 10.1002/ijc.32552
Abstract: Histone demethylases are promising therapeutic targets as they play fundamental roles for survival of Mixed lineage leukemia rearranged acute leukemia (MLLr AL). Here we focused on the catalytic Jumonji domain of histone H3 lysine 9… read more here.
Keywords: jdi; leukemia cells; jdi jdi; molecular modulators ... See more keywords
Arrayed Molecular Barcoding of Leukemic Stem Cells.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0810-4_21
Abstract: Functional screens on cancer cells using compound or protein libraries are usually performed in vitro. However, to assess the effects on leukemia stem cells (LSCs) in a screening setting, methodologies that allow for a high-throughput… read more here.
Keywords: leukemia cells; molecular barcoding; stem cells; arrayed molecular ... See more keywords
Targeted blocking of miR328 lysosomal degradation with alkalized exosomes sensitizes the chronic leukemia cells to imatinib
Sign Up to like & getrecommendations! Published in 2019 at "Applied Microbiology and Biotechnology"
DOI: 10.1007/s00253-019-10127-3
Abstract: Imatinib resistance remains the biggest hurdle for the treatment of chronic myeloid leukemia (CML), with the underlying mechanisms not fully understood. In this study, we found that miR328 significantly and strikingly decreased among other miRNA… read more here.
Keywords: chronic leukemia; leukemia cells; alkalized exosomes; mir328 ... See more keywords
Genistein-induced Anticancer Effects on Acute Leukemia Cells Involve the Regulation of Wnt Signaling Pathway Through H4K20me1 Rather Than DNA Demethylation
Sign Up to like & getrecommendations! Published in 2021 at "Current Medical Science"
DOI: 10.1007/s11596-021-2445-8
Abstract: To investigate the effects and mechanisms of genistein on the gene expression in the Wnt pathway in acute leukemia (AL) cells. The expression of Wnt pathway genes and cell cycle-related genes were analyzed in two… read more here.
Keywords: genistein; leukemia cells; cell cycle; acute leukemia ... See more keywords
Induction of apoptosis and differentiation by Na/H exchanger 1 modulation in acute myeloid leukemia cells.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.09.087
Abstract: We investigated the effect of the modulation of Na/H exchanger 1 (NHE1) on apoptosis, differentiation, and chemoresistance in acute myeloid leukemia (AML) cells to evaluate the possibility of NHE1 modulation as a novel therapeutic strategy… read more here.
Keywords: leukemia cells; modulation; leukemia; apoptosis differentiation ... See more keywords
Morphine activates blast-phase chronic myeloid leukemia cells and alleviates the effects of tyrosine kinase inhibitors.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.10.067
Abstract: Morphine is an opioid analgesic drug routinely used in the postoperative period for pain management in cancer patients. In this work, we analyzed the effects of morphine on leukemia cells at all stages of development… read more here.
Keywords: blast phase; cml; morphine; leukemia cells ... See more keywords
Design, synthesis and anti leukemia cells proliferation activities of pyrimidylaminoquinoline derivatives as DOT1L inhibitors.
Sign Up to like & getrecommendations! Published in 2018 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2018.07.022
Abstract: A series of novel pyrimidylaminoquinoline derivatives 8(a-i) and 9(a-i) containing amino side chain, and the bisaminoquinoline analogs 3(b-e) have been designed and synthesized by structural modifications on a lead DOT1L inhibitor, 3a. All the compounds… read more here.
Keywords: leukemia cells; proliferation activities; pyrimidylaminoquinoline derivatives; cells proliferation ... See more keywords
Leukemia cells apoptosis by a newly discovered heterogeneous polysaccharide from Angelica sinensis (Oliv.) Diels.
Sign Up to like & getrecommendations! Published in 2020 at "Carbohydrate polymers"
DOI: 10.1016/j.carbpol.2020.116279
Abstract: Galectin-3 (Gal-3) is a potential target for acute myeloid leukemia therapeutics which contains a carbohydrate-recognition domain. However, the development of polysaccharide inhibitors against Gal-3 is insufficient. In this research, we found a polysaccharide from Angelica… read more here.
Keywords: leukemia cells; polysaccharide angelica; sinensis oliv; cells apoptosis ... See more keywords
Targeting the Residual Leukemia Cells after Chemotherapy.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer cell"
DOI: 10.1016/j.ccell.2018.08.012
Abstract: One of the biggest challenges in treating acute myeloid leukemia (AML) is relapse of aggressive disease after treatment. In this issue of Cancer Cell, Boyd et al. characterize a molecularly distinct population of chemotherapy-induced transient leukemic regenerating… read more here.
Keywords: targeting residual; residual leukemia; leukemia cells; cells chemotherapy ... See more keywords
CHAF1B Overexpression: A Brake for the Differentiation of Leukemia Cells.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer cell"
DOI: 10.1016/j.ccell.2018.10.011
Abstract: In this issue of Cancer Cell, Volk et al. report that overexpression of CHAF1B displaces myeloid transcription factors from chromatin, and deletion of CHAF1B promotes differentiation of leukemia cells and suppresses leukemogenesis in a murine model,… read more here.
Keywords: leukemia cells; differentiation leukemia; chaf1b overexpression;
SMALL-MOLECULE TELOMERE INHIBITOR ATTENUATES THE LEUKEMIA-INITIATION POTENTIAL IN DRUG-RESISTANT LEUKEMIA CELLS
Sign Up to like & getrecommendations! Published in 2019 at "Experimental Hematology"
DOI: 10.1016/j.exphem.2019.06.364
Abstract: The drug resistance is the most often obstacle in leukemia treatment and failing to eradicating the quiescent leukemia stem cell (LSCs) is believed as the main reason of relapse. Numerous studies have indicated that abnormal… read more here.
Keywords: leukemia; drug; resistant leukemia; drug resistant ... See more keywords