Abstract 1732: Functional characterization of the impact of CD36 deletion on normal hematopoiesis and the leukemia microenvironment
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DOI: 10.1158/1538-7445.am2023-1732
Abstract: CD36 has been identified as a potential therapeutic target both in the leukemic cells and in the tumor immune microenvironment. CD36 also plays a role in lipid metabolism of cancer associated T-cells leading to impaired… read more here.
Keywords: cd36; impact; cd36 mice; mice ... See more keywords
Inhibiting efferocytosis reverses macrophage-mediated immunosuppression in the leukemia microenvironment
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1146721
Abstract: Background Previous studies show that the spleen and bone marrow can serve as leukemia microenvironments in which macrophages play a significant role in immune evasion and chemoresistance. We hypothesized that the macrophage driven tolerogenic process… read more here.
Keywords: efferocytosis; leukemia; expression; macrophage ... See more keywords