Prediction of outcomes in chronic lymphocytic leukemia patients treated with ibrutinib: Validation of current prognostic models and development of a simplified three‐factor model
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DOI: 10.1002/ajh.26502
Abstract: apixaban with major ischemic or hemorrhagic events in patients with atrial fibrillation. JAMA. 2021;326(23):2395-2404. 3. Ortel TL, Neumann I, Ageno W, et al. American Society of Hematology 2020 guidelines for management of venous thromboembolism: treatment… read more here.
Keywords: hematology; chronic lymphocytic; outcomes chronic; lymphocytic leukemia ... See more keywords
TSC gene expression in the newly diagnosed Egyptian acute leukemia patients
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DOI: 10.1007/s00580-018-2722-5
Abstract: TSC (tuberous sclerosis) complex is the major negative regulator of mTOR which activates cell cycle progression leading to uncontrolled growth. Acute leukemias are very heterogeneous as a group of hematological malignancies; they arise as a… read more here.
Keywords: tsc gene; gene expression; acute leukemia; leukemia patients ... See more keywords
Evaluating the expression level of Survivin gene in different groups of B-cell acute lymphoblastic leukemia patients of Iran
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DOI: 10.1007/s11033-019-04703-z
Abstract: Survivin is one of the major members of Inhibitory Apoptotic Proteins (IAP) family. The functional anti-apoptotic and regulatory role of Survivin in the cell cycle had made it as an interesting candidate for tumor studies.… read more here.
Keywords: cell acute; lymphoblastic leukemia; expression; acute lymphoblastic ... See more keywords
A Multi-disciplinary Approach to Managing Chronic Myelogenous Leukemia Patients on Oral Anticancer Therapy at a Large Academic Medical Center
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DOI: 10.1007/s11899-021-00659-9
Abstract: Since the discovery of imatinib, an oral breakpoint cluster region—Abelson murine leukemia tyrosine kinase inhibitor, chronic myelogenous leukemia transformed from a hematologic malignancy primarily treated with intravenous chemotherapy to a disease almost solely managed with… read more here.
Keywords: oral anticancer; large academic; chronic myelogenous; myelogenous leukemia ... See more keywords
Ibrutinib in previously treated chronic lymphocytic leukemia patients with autoimmune cytopenias in the RESONATE study
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DOI: 10.1038/bcj.2017.5
Abstract: Ibrutinib in previously treated chronic lymphocytic leukemia patients with autoimmune cytopenias in the RESONATE study read more here.
Keywords: previously treated; lymphocytic leukemia; treated chronic; leukemia patients ... See more keywords
Validation of genes for H-ARS severity prediction in leukemia patients - interspecies comparison, challenges, and promises
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DOI: 10.1080/09553002.2023.2295295
Abstract: Abstract Purpose In a previous baboon-study, a total of 29 genes were identified for clinical outcome prediction of the hematologic, acute, radiation, syndrome (H-ARS) severity. Among them, four genes (FDXR, DDB2, POU2AF1, WNT3) appeared promising… read more here.
Keywords: leukemia; prediction; exposure; ars severity ... See more keywords
TcRαβ-depleted haploidentical transplantation results in adult acute leukemia patients
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DOI: 10.1080/10245332.2016.1238182
Abstract: ABSTRACT Introduction: The use of αβ+ T-cell-depleted grafts is a novel approach to prevent graft failure, graft-versus-host disease (GVHD), and non-relapse mortality (NRM) in patients undergoing haploidentical hematopoietic stem cell transplantation. Patient and method: Thirty-four… read more here.
Keywords: depleted haploidentical; acute leukemia; transplantation; leukemia patients ... See more keywords
Decreased expression of HBA1 and HBB genes in acute myeloid leukemia patients and their inhibitory effects on growth of K562 cells
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DOI: 10.1080/16078454.2022.2117186
Abstract: ABSTRACT Background Besides the traditional roles of HBA1 and HBB, recent findings suggest that hemoglobin genes may have roles in other contexts. Objective In the present study, we aim to investigate a possible tumor-suppressor role… read more here.
Keywords: myeloid leukemia; leukemia patients; acute myeloid; hba1 hbb ... See more keywords
Exploring risk factors and molecular targets in leukemia patients with COVID-19: a bioinformatics analysis of differential gene expression.
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DOI: 10.1093/jleuko/qiae002
Abstract: The molecular mechanism of COVID-19's pathogenic effects in leukemia patients is still poorly known. Our study investigated the possible disease mechanism of COVID-19 and its associated risk factors in patients with leukemia utilizing differential gene… read more here.
Keywords: differential gene; covid; risk factors; expression ... See more keywords
Monitoring of cytomegalovirus infection in non-transplant pediatric acute lymphoblastic leukemia patients during chemotherapy
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DOI: 10.1097/md.0000000000014256
Abstract: Abstract Cytomegalovirus (CMV) infection is a significant cause of morbidity and mortality in the posttransplant setting; however, it is increasingly recognized in pediatric leukemia during chemotherapy. This study assessed the prevalence and associated factors of… read more here.
Keywords: infection; cmv dnaemia; cmv; leukemia patients ... See more keywords
Polo-like Kinase 4: the Variation During Therapy and its Relation to Treatment Response and Prognostic Risk Stratification in Childhood Acute Lymphoblastic Leukemia Patients
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DOI: 10.1097/mph.0000000000002520
Abstract: Polo-like kinase 4 (PLK4) plays an essential role in the tumorigenesis of some blood malignancies; consequently, we hypothesized that PLK4 might serve as a potential biomarker in childhood acute lymphoblastic leukemia (ALL) patients. Therefore, this… read more here.
Keywords: childhood; leukemia patients; lymphoblastic leukemia; acute lymphoblastic ... See more keywords