Myeloproliferative leukemia protein activation directly induces fibrocyte differentiation to cause myelofibrosis
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DOI: 10.1038/leu.2017.112
Abstract: Myelofibrosis (MF) may be caused by various pathogenic mechanisms such as elevation in circulating cytokine levels, cellular interactions and genetic mutations. However, the underlying mechanism of MF still remains unknown. Recent studies have revealed that… read more here.
Keywords: fibrocyte differentiation; leukemia protein; activation; myeloproliferative leukemia ... See more keywords
C-terminal motifs in promyelocytic leukemia protein isoforms critically regulate PML nuclear body formation
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DOI: 10.1242/jcs.202879
Abstract: ABSTRACT Promyelocytic leukemia protein (PML) nuclear bodies (NBs), which are sub-nuclear protein structures, are involved in a variety of important cellular functions. PML-NBs are assembled by PML isoforms, and contact between small ubiquitin-like modifiers (SUMOs)… read more here.
Keywords: protein; promyelocytic leukemia; pml nuclear; formation ... See more keywords