HERVs characterize normal and leukemia stem cells and represent a source of shared epitopes for cancer immunotherapy
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Hematology"
DOI: 10.1002/ajh.26647
Abstract: Human endogenous retroviruses (HERVs) represent 8% of the human genome. The expression of HERVs and their immune impact have not been extensively studied in Acute Myeloid Leukemia (AML). In this study, we used a reference… read more here.
Keywords: leukemia stem; source; hervs; stem cells ... See more keywords
The cell of origin and the leukemia stem cell in acute myeloid leukemia
Sign Up to like & getrecommendations! Published in 2019 at "Genes"
DOI: 10.1002/gcc.22805
Abstract: There is experimental and observational evidence that the cells of the leukemic clone in acute myeloid leukemia (AML) have different phenotypes even though they share the same somatic mutations. The organization of the malignant clone… read more here.
Keywords: cell; myeloid leukemia; acute myeloid; leukemia ... See more keywords
E35 ablates acute leukemia stem and progenitor cells in vitro and in vivo
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.29457
Abstract: Leukemia stem cells (LSCs) have critical functions in acute leukemia (AL) pathogenesis, participating in its initiation and relapse. Thus, identifying new molecules to eradicate LSCs represents a high priority for AL management. This work identified… read more here.
Keywords: progenitor cells; acute leukemia; stem progenitor; stem ... See more keywords
Leukemia Stem Cell Drug Discovery.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0810-4_3
Abstract: The relative survival of cancer patients, when considering the tumoral stage at diagnosis, has not changed significantly in the last three decades, in spite of our increasingly detailed knowledge of the molecular alterations occurring in… read more here.
Keywords: cell drug; drug; stem cell; cancer ... See more keywords
Leukemia Stem Cells Microenvironment.
Sign Up to like & getrecommendations! Published in 2017 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-319-69194-7_3
Abstract: The dynamic interactions between leukemic cells and bone marrow (BM) cells in the leukemia BM microenvironment regulate leukemia stem cell (LSC) properties including localization, self-renewal, differentiation, and proliferation. Recent research of normal and leukemia BM… read more here.
Keywords: microenvironment; biology; leukemia; stem cells ... See more keywords
Tissue "Hypoxia" and the Maintenance of Leukemia Stem Cells.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-13-7342-8_6
Abstract: The relationship of the homing of normal hematopoietic stem cells (HSC) in the bone marrow to specific environmental conditions, referred to as the stem cell niche (SCN), has been intensively studied over the last three… read more here.
Keywords: stem cells; maintenance; stem cell; stem ... See more keywords
DNA Damage Response in Quiescent Hematopoietic Stem Cells and Leukemia Stem Cells.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-13-7342-8_7
Abstract: In humans, hematopoietic stem cells (HSCs) adopt unique responsive pathways counteracting with the DNA-damaging assaults to weigh the balance between the maintenance of normal stem cell poor for whole-life blood regeneration and the transformation to… read more here.
Keywords: dna damage; damage response; hematopoietic stem; stem ... See more keywords
Inflammation-driven deaminase deregulation fuels human pre-leukemia stem cell evolution.
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2020.108670
Abstract: Inflammation-dependent base deaminases promote therapeutic resistance in many malignancies. However, their roles in human pre-leukemia stem cell (pre-LSC) evolution to acute myeloid leukemia stem cells (LSCs) had not been elucidated. Comparative whole-genome and whole-transcriptome sequencing… read more here.
Keywords: evolution; human pre; stem; pre lsc ... See more keywords
Sulforaphane regulates the proliferation of leukemia stem-like cells via Sonic Hedgehog signaling pathway.
Sign Up to like & getrecommendations! Published in 2022 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2022.174824
Abstract: Sulforaphane (SFN), the main ingredient in broccoli/broccoli sprouts, has a good anticancer effect in a wide variety of tumors, but whether SFN affects acute leukemia is not elucidated. Due to the self-renewal capability for leukemia… read more here.
Keywords: stem like; like cells; leukemia stem; stem ... See more keywords
A rare subgroup of leukemia stem cells harbors relapse-inducing potential in acute lymphoblastic leukemia.
Sign Up to like & getrecommendations! Published in 2019 at "Experimental hematology"
DOI: 10.1016/j.exphem.2018.09.006
Abstract: After initially successful chemotherapy, relapse frequently jeopardizes the outcome of patients with acute leukemia. Because of their adverse characteristics of self-renewal and dormancy, leukemia stem cells have been hypothesized to play a critical role in… read more here.
Keywords: stem cells; lymphoblastic leukemia; acute lymphoblastic; stem ... See more keywords
Leukemogenic Chromatin Alterations Promote AML Leukemia Stem Cells via a KDM4C-ALKBH5-AXL Signaling Axis.
Sign Up to like & getrecommendations! Published in 2020 at "Cell stem cell"
DOI: 10.1016/j.stem.2020.04.001
Abstract: N6-methyladenosine (m6A) is a commonly present modification of mammalian mRNAs and plays key roles in various cellular processes. m6A modifiers catalyze this reversible modification. However, the underlying mechanisms by which these m6A modifiers are regulated… read more here.
Keywords: m6a modifiers; alkbh5; leukemia stem; stem ... See more keywords