Inhibition of CD38 Shows Anti-Leukemic Activity in Acute Myeloid Leukemia
Sign Up to like & getrecommendations! Published in 2018 at "Blood"
DOI: 10.1182/blood-2018-99-113287
Abstract: Acute myeloid leukemia (AML) is characterized by an early failure of healthy hematopoiesis and a high relapse rate, caused by persistent leukemia initiating cells in the bone marrow niche. The hematopoietic stem cell niche in… read more here.
Keywords: anti leukemic; cd38; leukemic activity; aml ... See more keywords
Selective ERK1/2 agonists isolated from Melia azedarach with potent anti-leukemic activity
Sign Up to like & getrecommendations! Published in 2019 at "BMC Cancer"
DOI: 10.1186/s12885-019-5914-8
Abstract: BackgroundMAPK/ERK kinases transmit signals from many growth factors/kinase receptors during normal cell growth/differentiation, and their dysregulation is a hallmark of diverse types of cancers. A plethora of drugs were developed to block this kinase pathway… read more here.
Keywords: anti leukemic; potent anti; erk1; leukemic activity ... See more keywords
The γ-secretase inhibitors enhance the anti-leukemic activity of ibrutinib in B-CLL cells.
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.19494
Abstract: Ibrutinib blocks B-cell receptor signaling and interferes with leukemic cell-to-microenvironment interactions. Ibrutinib plays a key role in the management of B-CLL and is recommended for first line treatment of high-risk CLL patients with 17p deletion.… read more here.
Keywords: cll; ibrutinib; anti leukemic; leukemic activity ... See more keywords