Measurement of Leukemic B-Cell Growth Kinetics in Patients with Chronic Lymphocytic Leukemia.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8876-1_11
Abstract: Cell proliferation plays a central role in the pathogenesis of every neoplastic disease as well as many other types of illness. Labeling of newly replicated DNA with deuterium (2H), a nonradioactive isotope of hydrogen, administered… read more here.
Keywords: measurement leukemic; lymphocytic leukemia; leukemic cell; chronic lymphocytic ... See more keywords
Disease-inducing potential of two leukemic cell lines in a xenografting model
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Assisted Reproduction and Genetics"
DOI: 10.1007/s10815-021-02169-2
Abstract: Cryopreserved ovarian tissue transplant restores ovarian function in young cancer patients after gonadotoxic treatment. However, leukemia is associated with increased risk of malignant cell transmission. We aimed to assess the tumor-inducing potential of two different… read more here.
Keywords: potential two; leukemic cell; cell lines; disease ... See more keywords
Induction of resistance to chimeric antigen receptor T cell therapy by transduction of a single leukemic B cell
Sign Up to like & getrecommendations! Published in 2018 at "Nature Medicine"
DOI: 10.1038/s41591-018-0201-9
Abstract: We report a patient relapsing 9 months after CD19-targeted CAR T cell (CTL019) infusion with CD19– leukemia that aberrantly expressed the anti-CD19 CAR. The CAR gene was unintentionally introduced into a single leukemic B cell… read more here.
Keywords: leukemic cell; resistance; therapy; cell ... See more keywords
Metabolic abnormalities in adult T-cell leukemia/lymphoma and induction of specific leukemic cell death using photodynamic therapy
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-33175-7
Abstract: Adult T-cell leukemia/lymphoma (ATL) is an aggressive T-cell neoplasm caused by human T-cell leukemia virus type I (HTLV-I). Therapeutic interventions have not been associated with satisfactory outcomes. We showed that the porphyrin metabolic pathway preferentially… read more here.
Keywords: leukemic cell; cell leukemia; leukemia lymphoma; adult cell ... See more keywords
A Novel Peptide Derived from Ginger Induces Apoptosis through the Modulation of p53, BAX, and BCL2 Expression in Leukemic Cell Lines.
Sign Up to like & getrecommendations! Published in 2021 at "Planta medica"
DOI: 10.1055/a-1408-5629
Abstract: Despite the efficacy of chemotherapy, the adverse effects of chemotherapeutic drugs are considered a limitation of leukemia treatment. Therefore, a chemotherapy drug with minimal side effects is currently needed. One interesting molecule for this purpose… read more here.
Keywords: leukemic cell; cell lines; treatment; expression ... See more keywords
Novel small molecule SIRT2 inhibitors induce cell death in leukemic cell lines
Sign Up to like & getrecommendations! Published in 2018 at "BMC Cancer"
DOI: 10.1186/s12885-018-4710-1
Abstract: BackgroundSirtuin 2 (SIRT2) is a member of the sirtuin family, nicotinamide adenine dinucleotide+-dependent deacylases, which participates in modulation of cell cycle control, neurodegeneration, and tumorigenesis. SIRT2 expression increases in acute myeloid leukemia blasts. Downregulation of… read more here.
Keywords: leukemic cell; sirt2; cell lines; cell death ... See more keywords
Improved classification of leukemic B-cell lymphoproliferative disorders using a transcriptional and genetic classifier
Sign Up to like & getrecommendations! Published in 2017 at "Haematologica"
DOI: 10.3324/haematol.2016.160374
Abstract: Supplementary figures are available from the publisher website at http://www.haematologica.org/content/102/9/e360.figures-only read more here.
Keywords: cell lymphoproliferative; leukemic cell; disorders using; improved classification ... See more keywords
RUNX1 Upregulates CENPE to Promote Leukemic Cell Proliferation
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2021.692880
Abstract: RUNX1 is a Runt family transcription factor that plays a critical role in normal hematopoiesis, including the differentiation and proliferation of hematopoietic cells. RUNX1 mutations, including chromosomal translocations, cause abnormal cell differentiation, but the mutation… read more here.
Keywords: cell; leukemic cell; cell proliferation; runx1 ... See more keywords
Corrigendum: RUNX1 Upregulates CENPE to Promote Leukemic Cell Proliferation
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2022.834509
Abstract: [This corrects the article DOI: 10.3389/10.3389/fmolb.2021.692880.]. read more here.
Keywords: runx1 upregulates; leukemic cell; cenpe promote; upregulates cenpe ... See more keywords
Mutant NPM1-Regulated FTO-Mediated m6A Demethylation Promotes Leukemic Cell Survival via PDGFRB/ERK Signaling Axis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.817584
Abstract: Acute myeloid leukemia (AML) with nucleophosmin 1 (NPM1) mutations exhibits distinct biological and clinical features, accounting for approximately one-third of AML. Recently, the N6-methyladenosine (m6A) RNA modification has emerged as a new epigenetic modification to… read more here.
Keywords: leukemic cell; erk signaling; pdgfrb erk; signaling axis ... See more keywords
Deubiquitinase Inhibitors Impair Leukemic Cell Migration Through Cofilin Oxidation and Alteration of Actin Reorganization
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.778216
Abstract: Actin networks are dynamically regulated through constant depolymerization and polymerization cycles. Although the fundamental mechanisms that govern these processes have been identified, the nature and role of post-translational modifications (PTMs) of actin and actin regulatory… read more here.
Keywords: actin; cofilin; leukemic cell; cell ... See more keywords