Pharmacological degradation of ATR induces antiproliferative DNA replication stress in leukemic cells
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13638
Abstract: Mammalian cells replicate ~ 3 × 109 base pairs per cell cycle. One of the key molecules that slows down the cell cycle and prevents excessive DNA damage upon DNA replication stress is the checkpoint kinase ataxia‐telangiectasia‐and‐RAD3‐related (ATR).… read more here.
Keywords: replication stress; dna replication; atr; leukemic cells ... See more keywords
Effects of some 5-anilino-1,2,4-thiadiazole derivatives onto leukemic cells
Sign Up to like & getrecommendations! Published in 2017 at "Russian Chemical Bulletin"
DOI: 10.1007/s11172-017-1833-5
Abstract: The antileukemic activities of some thiadiazole derivatives in the forms of hydrochlorides and salicylates have been determined. The insertion of salicylate ion in the compound increases the therapeutic index, mainly due to the reduction of… read more here.
Keywords: derivatives onto; leukemic cells; effects anilino; anilino thiadiazole ... See more keywords
Chemotherapy Impedes In Vitro Microcirculation and Promotes Migration of Leukemic Cells with Impact on Metastasis
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.691
Abstract: Although most cancer drugs target the proliferation of cancer cells, it is metastasis, the complex process by which cancer cells spread from the primary tumor to other tissues and organs of the body where they… read more here.
Keywords: cancer drugs; leukemic cells; metastasis; cancer cells ... See more keywords
Leukemic Cells "Gas Up" Leaky Bone Marrow Blood Vessels.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer cell"
DOI: 10.1016/j.ccell.2017.08.012
Abstract: In this issue of Cancer Cell, Passaro et al. demonstrate how leukemia through aberrant induction of reactive oxygen species and nitric oxide production trigger marrow vessel leakiness, instigating pro-leukemic function. Disrupted tumor blood vessels promote exhaustion… read more here.
Keywords: leukemic cells; cells gas; gas leaky; blood ... See more keywords
Parasitic Behavior of Leukemic Cells in Systemic Host Metabolism.
Sign Up to like & getrecommendations! Published in 2018 at "Cell metabolism"
DOI: 10.1016/j.cmet.2018.11.011
Abstract: Metabolic reprogramming is a hallmark of cancer cell metabolism. Recently, in Cancer Cell, Ye and colleagues (2018) reported that leukemic cells have the capacity to modulate glucose metabolism in multiple organs of their host, thereby… read more here.
Keywords: leukemic cells; metabolism parasitic; metabolism; parasitic behavior ... See more keywords
Knockdown of the Wnt receptor Frizzled-1 (FZD1) reduces MDR1/P-glycoprotein expression in multidrug resistant leukemic cells and inhibits leukemic cell proliferation.
Sign Up to like & getrecommendations! Published in 2018 at "Leukemia research"
DOI: 10.1016/j.leukres.2018.01.020
Abstract: Multidrug resistance (MDR) is a major obstacle to leukemia treatment. The Frizzled-1 (FZD1) Wnt receptor is involved in MDR in some solid cancers, but has rarely been reported to act in acute myeloid leukemia (AML).… read more here.
Keywords: frizzled fzd1; leukemic cells; wnt receptor; expression ... See more keywords
Activation of the complement cascade enhances motility of leukemic cells by downregulating expression of HO-1
Sign Up to like & getrecommendations! Published in 2017 at "Leukemia"
DOI: 10.1038/leu.2016.198
Abstract: As a crucial arm of innate immunity, the complement cascade (ComC) is involved both in mobilization of normal hematopoietic stem/progenitor cells (HSPCs) from bone marrow (BM) into peripheral blood and in their homing to BM.… read more here.
Keywords: cell; complement cascade; leukemic cells; enhances motility ... See more keywords
Restoration of microRNA function impairs MYC-dependent maintenance of MLL leukemia
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DOI: 10.1038/s41375-020-0768-2
Abstract: MicroRNAs (miRNAs) are a class of small noncoding RNAs that have critical functions in gene silencing by binding to complementary mRNAs to induce their degradation or translational repression [1]. Interestingly, only a small fraction of… read more here.
Keywords: leukemic cells; mll leukemic; function; mll ... See more keywords
Targeting of IRAK4 and GSPT1 enhances therapeutic efficacy in AML via c-Myc destabilization
Sign Up to like & getrecommendations! Published in 2025 at "Leukemia"
DOI: 10.1038/s41375-025-02695-3
Abstract: IRAK4 is a therapeutic target in myeloid malignancies, but current IRAK4 inhibitors show only modest clinical efficacy in acute myeloid leukemia, highlighting the need for combination strategies. To identify drugs with synergistic potential alongside IRAK4… read more here.
Keywords: leukemic cells; aml; irak4; efficacy ... See more keywords
Different immunotherapeutic combinations enhance specific T cell immune responses against leukemic cells, as well as leukemic progenitor cells, in acute myeloid leukemia.
Sign Up to like & getrecommendations! Published in 2025 at "Leukemia"
DOI: 10.1038/s41375-025-02764-7
Abstract: Immunotherapeutic approaches have become increasingly important in cancer therapy, including for patients with acute myeloid leukemia (AML). Despite being shown to be effective in the context of stem cell transplants for almost 50 years, further… read more here.
Keywords: leukemic progenitor; leukemic cells; responses leukemic; immune responses ... See more keywords
Transcript-indexed ATAC-seq for precision immune profiling
Sign Up to like & getrecommendations! Published in 2018 at "Nature medicine"
DOI: 10.1038/s41591-018-0008-8
Abstract: T cells create vast amounts of diversity in the genes that encode their T cell receptors (TCRs), which enables individual clones to recognize specific peptide–major histocompatibility complex (MHC) ligands. Here we combined sequencing of the… read more here.
Keywords: leukemic cells; atac seq; transcript indexed; indexed atac ... See more keywords