The Adaptive Remodeling of Stem Cell Niche in Stimulated Bone Marrow Counteracts the Leukemic Niche
Sign Up to like & getrecommendations! Published in 2018 at "STEM CELLS"
DOI: 10.1002/stem.2870
Abstract: Accumulating studies have shown the cellular nature of hematopoietic stem cell (HSC) niche in bone marrow (BM) and their degenerative changes under leukemic conditions. However, the dynamic adaptation of niche cells to changes in physiological… read more here.
Keywords: leukemic niche; stem cell; niche; stem ... See more keywords
Extracellular vesicles impose quiescence on residual hematopoietic stem cells in the leukemic niche
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DOI: 10.15252/embr.201847546
Abstract: Progressive remodeling of the bone marrow microenvironment is recognized as an integral aspect of leukemogenesis. Expanding acute myeloid leukemia (AML) clones not only alter stroma composition, but also actively constrain hematopoiesis, representing a significant source… read more here.
Keywords: extracellular vesicles; hsc; leukemic niche; hematopoietic stem ... See more keywords
Phenotypic and Functional Alterations of Hematopoietic Stem and Progenitor Cells in an In Vitro Leukemia-Induced Microenvironment
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DOI: 10.3390/ijms18020199
Abstract: An understanding of the cell interactions occurring in the leukemic microenvironment and their functional consequences for the different cell players has therapeutic relevance. By co-culturing mesenchymal stem cells (MSC) with the REH acute lymphocytic leukemia… read more here.
Keywords: leukemic niche; hspc; hematopoietic stem; stem ... See more keywords