Glutathione-Bioimprinted Nanoparticles Targeting of N6-methyladenosine FTO Demethylase as a Strategy against Leukemic Stem Cells.
Sign Up to like & getrecommendations! Published in 2022 at "Small"
DOI: 10.1002/smll.202106558
Abstract: The N6-methyladenosine (m6 A) demethylase FTO plays an oncogenic role in acute myeloid leukemia (AML). Despite the promising recent progress for developing some small-molecule FTO inhibitors, the clinical potential remains limited due to mild biological… read more here.
Keywords: fto; methyladenosine; stem cells; leukemic stem ... See more keywords
In-Depth Mass Spectrometry-Based Single-Cell and Nanoscale Proteomics.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0810-4_10
Abstract: Leukemic stem cells are highly dynamic and heterogeneous. Analysis of leukemic stem cells at the single-cell level should provide a wealth of insights that would not be possible using bulk measurements. Mass spectrometry (MS)-based proteomic… read more here.
Keywords: single cell; mass spectrometry; leukemic stem; spectrometry based ... See more keywords
Signaling Pathways in Leukemic Stem Cells.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-13-7342-8_1
Abstract: Hematopoietic stem cells (HSCs) and leukemic stem cells (LSCs) utilize many of the same signaling pathways for their maintenance and survival. In this review, we will focus on several signaling pathways whose roles have been… read more here.
Keywords: signaling pathways; pathways leukemic; leukemic stem; stem cells ... See more keywords
Hematopoietic versus leukemic stem cell quiescence: Challenges and therapeutic opportunities.
Sign Up to like & getrecommendations! Published in 2021 at "Blood reviews"
DOI: 10.1016/j.blre.2021.100850
Abstract: Hematopoietic stem cells (HSC) are responsible for the production of mature blood cells. To ensure that the HSC pool does not get exhausted over the lifetime of an individual, most HSCs are in a state… read more here.
Keywords: quiescence; hematopoietic versus; versus leukemic; stem cell ... See more keywords
Leukemic stem cells activate lineage inappropriate signalling pathways to promote their growth
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-45691-4
Abstract: Acute Myeloid Leukemia (AML) is caused by multiple mutations which dysregulate growth and differentiation of myeloid cells. Cells adopt different gene regulatory networks specific to individual mutations, maintaining a rapidly proliferating blast cell population with… read more here.
Keywords: signalling pathways; stem cells; cells activate; leukemic stem ... See more keywords
Resolving leukemic stem cell heterogeneity and plasticity with single-cell multiomics.
Sign Up to like & getrecommendations! Published in 2025 at "Seminars in hematology"
DOI: 10.1053/j.seminhematol.2025.07.001
Abstract: Acute myeloid leukemia (AML) is an aggressive blood cancer in which disease initiation and relapse are driven by leukemic cells with stem-like properties, known as leukemic stem cells (LSCs). The LSC compartment is highly heterogenous… read more here.
Keywords: single cell; plasticity; cell multiomics; cell ... See more keywords
Dietary Turmeric Bisdemethoxycurcumin Suppresses Wilms’ Tumor 1 and CD34 Protein Expressions in KG-1a Leukemic Stem Cells
Sign Up to like & getrecommendations! Published in 2019 at "Nutrition and Cancer"
DOI: 10.1080/01635581.2019.1598565
Abstract: Abstract Leukemic cells remaining in the body is the main problem for cancer patients, and these cells are called Leukemic Stem Cells (LSCs). Many studies have revealed that the overexpression of the Wilms’ tumor 1… read more here.
Keywords: cd34 protein; leukemic stem; protein expressions;
Investigating the Effects of a Synthetic Cannabinoid on the Pathogenesis of Leukemia and Leukemic Stem Cells: A New Therapeutic Approach.
Sign Up to like & getrecommendations! Published in 2022 at "Cannabis and cannabinoid research"
DOI: 10.1089/can.2021.0180
Abstract: The popularity and usage of synthetic cannabinoids (SCs) are increasing due to their easy accessibility and psychoactive effects worldwide. Studies on cannabinoids on leukemic stem cells (LSC) and hematopoietic stem cells (HSCs), which are the… read more here.
Keywords: jwh 018; therapeutic approach; leukemia; leukemic stem ... See more keywords
MRP1 protein expression in leukemic stem cells as a negative prognostic marker in acute myeloid leukemia patients
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Haematology"
DOI: 10.1111/ejh.12938
Abstract: It is well established that expression of multi‐drug resistance (MDR) proteins (MDR1, BCRP, MDR3, MRP1, and LRP) in leukemic blasts correlates with acute myeloid leukemia (AML) patients’ clinical response. Assuming that leukemic stem cells (LSC)… read more here.
Keywords: myeloid leukemia; leukemic stem; expression; acute myeloid ... See more keywords
Targeting stem cells in myelodysplastic syndromes and acute myeloid leukemia
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Internal Medicine"
DOI: 10.1111/joim.13535
Abstract: The genetic architecture of cancer has been delineated through advances in high‐throughput next‐generation sequencing, where the sequential acquisition of recurrent driver mutations initially targeted towards normal cells ultimately leads to malignant transformation. Myelodysplastic syndromes (MDS)… read more here.
Keywords: myeloid leukemia; myelodysplastic syndromes; acute myeloid; stem ... See more keywords
Histone Deacetylase Inhibitor I3 Induces the Differentiation of Acute Myeloid Leukemia Cells with t (8; 21) or MLL Gene Translocation and Leukemic Stem-Like Cells
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Oncology"
DOI: 10.1155/2022/3345536
Abstract: Acute myeloid leukemia (AML) is a heterogeneous disorder characterized by the clonal expansion and differentiation arrest of leukemic cells in peripheral blood and bone marrow. Though the treatment using cytarabine-based protocol for AML patients with… read more here.
Keywords: myeloid leukemia; translocation; deacetylase inhibitor; acute myeloid ... See more keywords