The role of cell adhesion in hematopoiesis and leukemogenesis
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28636
Abstract: The cells of the bone marrow microenvironment are emerging as important contributors and regulators of normal hematopoiesis. This microenvironment is perturbed during leukemogenesis, and evidence points toward a bidirectional communication between leukemia cells and the… read more here.
Keywords: hematopoiesis; leukemogenesis; cell adhesion; role ... See more keywords
HOXA9 Reprograms the Enhancer Landscape to Promote Leukemogenesis.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer cell"
DOI: 10.1016/j.ccell.2018.08.018
Abstract: Aberrant expression of HOXA9 is a prominent feature of acute leukemia driven by diverse oncogenes. Here we show that HOXA9 overexpression in myeloid and B progenitor cells leads to significant enhancer reorganizations with prominent emergence… read more here.
Keywords: novo enhancers; leukemogenesis; hoxa9 reprograms; hoxa9 ... See more keywords
Somatic mtDNA mutation burden shapes metabolic plasticity in leukemogenesis
Sign Up to like & getrecommendations! Published in 2025 at "Science Advances"
DOI: 10.1126/sciadv.ads8489
Abstract: The role of somatic mitochondrial DNA (mtDNA) mutations in leukemogenesis remains poorly characterized. To determine the impact of somatic mtDNA mutations on this process, we assessed the leukemogenic potential of hematopoietic progenitor cells (HPCs) from… read more here.
Keywords: mutation burden; metabolic plasticity; somatic mtdna; mtdna mutation ... See more keywords
Abstract 657: IRAK1 regulated inflammatory signal from the leukemia cells modulates tumor microenvironment and promote leukemogenesis
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-657
Abstract: Hematologic malignancy associated with fibroblast growth factor receptor 1 (FGFR1) translocations develops an aggressive stem cell leukemia/lymphoma (SCLL), 80% of which progress to AML and only ~15% show survival of > 15 months. In addition,… read more here.
Keywords: cell; leukemia cells; leukemogenesis; leukemia ... See more keywords
UTX Promotes Chromatin Remodeling to Suppress Leukemogenesis.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-rw2018-082
Abstract: UTX-mediated suppression of myeloid leukemogenesis is independent of its demethylase activity. read more here.
Keywords: utx promotes; promotes chromatin; chromatin remodeling; leukemogenesis ... See more keywords
Upregulated heme biosynthesis, an exploitable vulnerability in MYCN-driven leukemogenesis.
Sign Up to like & getrecommendations! Published in 2017 at "JCI insight"
DOI: 10.1172/jci.insight.92409
Abstract: The increased heme biosynthesis long observed in leukemia was previously of unknown significance. Heme, synthesized from porphyrin precursors, plays a central role in oxygen metabolism and mitochondrial function, yet little is known about its role… read more here.
Keywords: heme; heme biosynthesis; leukemogenesis; mycn ... See more keywords
The Three E Proteins Define a Heterogeneity of the AML1-ETO-Containing Transcription Factor Complex (AETFC) and Differentially Regulate t(8;21) Leukemogenesis
Sign Up to like & getrecommendations! Published in 2018 at "Blood"
DOI: 10.1182/blood-2018-99-112372
Abstract: The leukemogenic AML1-ETO fusion protein is produced by the t(8;21) translocation, which is one of the most common chromosomal abnormalities in acute myeloid leukemia (AML). In leukemic cells, AML1-ETO resides in and functions through a… read more here.
Keywords: aml1 eto; three proteins; eto; leukemogenesis ... See more keywords
Activation of CaMKIIγ potentiates T-cell acute lymphoblastic leukemia leukemogenesis via phosphorylating FOXO3a
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.20504
Abstract: Ca2+/calmodulin–dependent protein kinase II γ (CaMKIIγ) can regulate the proliferation and differentiation of myeloid leukemia cells and accelerate chronic myeloid leukemia blast crisis, but the role of CaMKIIγ in T-cell acute lymphoblastic leukemia (T-ALL) leukemogenesis… read more here.
Keywords: cell acute; leukemogenesis; lymphoblastic leukemia; camkii ... See more keywords
Rac1/2 activation promotes FGFR1 driven leukemogenesis in stem cell leukemia/lymphoma syndrome
Sign Up to like & getrecommendations! Published in 2019 at "Haematologica"
DOI: 10.3324/haematol.2018.208058
Abstract: The Rac proteins are a subfamily of the Rho-GTPases which cycle between activated GTP-bound and inactivate GDP-bound forms to coordinate various cell responses with signals from extracellular stimuli. In particular, the Rac proteins play an… read more here.
Keywords: leukemogenesis; stem cell; activation; rac ... See more keywords
Effects of NRAS Mutations on Leukemogenesis and Targeting of Children With Acute Lymphoblastic Leukemia
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.712484
Abstract: Through the advancements in recent decades, childhood acute lymphoblastic leukemia (ALL) is gradually becoming a highly curable disease. However, the truth is there remaining relapse in ∼15% of ALL cases with dismal outcomes. RAS mutations,… read more here.
Keywords: acute lymphoblastic; ras mutations; leukemogenesis; nras mutations ... See more keywords
Unique role of DDX41, a DEAD-box type RNA helicase, in hematopoiesis and leukemogenesis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.992340
Abstract: In myeloid malignancies including acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS), patient selection and therapeutic strategies are increasingly based on tumor-specific genetic mutations. Among these, mutations in DDX41, which encodes a DEAD-box type RNA… read more here.
Keywords: ddx41; rna helicase; leukemogenesis; rna ... See more keywords