The role of cell adhesion in hematopoiesis and leukemogenesis
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28636
Abstract: The cells of the bone marrow microenvironment are emerging as important contributors and regulators of normal hematopoiesis. This microenvironment is perturbed during leukemogenesis, and evidence points toward a bidirectional communication between leukemia cells and the… read more here.
Keywords: hematopoiesis; leukemogenesis; cell adhesion; role ... See more keywords
HOXA9 Reprograms the Enhancer Landscape to Promote Leukemogenesis.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer cell"
DOI: 10.1016/j.ccell.2018.08.018
Abstract: Aberrant expression of HOXA9 is a prominent feature of acute leukemia driven by diverse oncogenes. Here we show that HOXA9 overexpression in myeloid and B progenitor cells leads to significant enhancer reorganizations with prominent emergence… read more here.
Keywords: novo enhancers; leukemogenesis; hoxa9 reprograms; hoxa9 ... See more keywords
Abstract 657: IRAK1 regulated inflammatory signal from the leukemia cells modulates tumor microenvironment and promote leukemogenesis
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-657
Abstract: Hematologic malignancy associated with fibroblast growth factor receptor 1 (FGFR1) translocations develops an aggressive stem cell leukemia/lymphoma (SCLL), 80% of which progress to AML and only ~15% show survival of > 15 months. In addition,… read more here.
Keywords: cell; leukemia cells; leukemogenesis; leukemia ... See more keywords
UTX Promotes Chromatin Remodeling to Suppress Leukemogenesis.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-rw2018-082
Abstract: UTX-mediated suppression of myeloid leukemogenesis is independent of its demethylase activity. read more here.
Keywords: utx promotes; promotes chromatin; chromatin remodeling; leukemogenesis ... See more keywords
Upregulated heme biosynthesis, an exploitable vulnerability in MYCN-driven leukemogenesis.
Sign Up to like & getrecommendations! Published in 2017 at "JCI insight"
DOI: 10.1172/jci.insight.92409
Abstract: The increased heme biosynthesis long observed in leukemia was previously of unknown significance. Heme, synthesized from porphyrin precursors, plays a central role in oxygen metabolism and mitochondrial function, yet little is known about its role… read more here.
Keywords: heme; heme biosynthesis; leukemogenesis; mycn ... See more keywords
The Three E Proteins Define a Heterogeneity of the AML1-ETO-Containing Transcription Factor Complex (AETFC) and Differentially Regulate t(8;21) Leukemogenesis
Sign Up to like & getrecommendations! Published in 2018 at "Blood"
DOI: 10.1182/blood-2018-99-112372
Abstract: The leukemogenic AML1-ETO fusion protein is produced by the t(8;21) translocation, which is one of the most common chromosomal abnormalities in acute myeloid leukemia (AML). In leukemic cells, AML1-ETO resides in and functions through a… read more here.
Keywords: aml1 eto; three proteins; eto; leukemogenesis ... See more keywords
Activation of CaMKIIγ potentiates T-cell acute lymphoblastic leukemia leukemogenesis via phosphorylating FOXO3a
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.20504
Abstract: Ca2+/calmodulin–dependent protein kinase II γ (CaMKIIγ) can regulate the proliferation and differentiation of myeloid leukemia cells and accelerate chronic myeloid leukemia blast crisis, but the role of CaMKIIγ in T-cell acute lymphoblastic leukemia (T-ALL) leukemogenesis… read more here.
Keywords: cell acute; leukemogenesis; lymphoblastic leukemia; camkii ... See more keywords
Rac1/2 activation promotes FGFR1 driven leukemogenesis in stem cell leukemia/lymphoma syndrome
Sign Up to like & getrecommendations! Published in 2019 at "Haematologica"
DOI: 10.3324/haematol.2018.208058
Abstract: The Rac proteins are a subfamily of the Rho-GTPases which cycle between activated GTP-bound and inactivate GDP-bound forms to coordinate various cell responses with signals from extracellular stimuli. In particular, the Rac proteins play an… read more here.
Keywords: leukemogenesis; stem cell; activation; rac ... See more keywords
Effects of NRAS Mutations on Leukemogenesis and Targeting of Children With Acute Lymphoblastic Leukemia
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.712484
Abstract: Through the advancements in recent decades, childhood acute lymphoblastic leukemia (ALL) is gradually becoming a highly curable disease. However, the truth is there remaining relapse in ∼15% of ALL cases with dismal outcomes. RAS mutations,… read more here.
Keywords: acute lymphoblastic; ras mutations; leukemogenesis; nras mutations ... See more keywords
Unique role of DDX41, a DEAD-box type RNA helicase, in hematopoiesis and leukemogenesis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.992340
Abstract: In myeloid malignancies including acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS), patient selection and therapeutic strategies are increasingly based on tumor-specific genetic mutations. Among these, mutations in DDX41, which encodes a DEAD-box type RNA… read more here.
Keywords: ddx41; rna helicase; leukemogenesis; rna ... See more keywords