β2 Integrin Gene (ITGB2) mutation spectra in Pakistani families with leukocyte adhesion deficiency type 1 (LAD1).
Sign Up to like & getrecommendations! Published in 2020 at "Immunobiology"
DOI: 10.1016/j.imbio.2020.151938
Abstract: Leukocyte adhesion deficiency I (LADI) is an autosomal recessive type of primary immunodeficiency characterized by occurrence of repeated bacterial infections, impaired pus formation and wound healing. Genetic variations in the β-2 integrin subunit encoding gene… read more here.
Keywords: gene itgb2; leukocyte adhesion; gene; adhesion deficiency ... See more keywords
A high-salt diet enhances leukocyte adhesion in association with kidney injury in young dahl salt-sensitive rats
Sign Up to like & getrecommendations! Published in 2017 at "Hypertension Research"
DOI: 10.1038/hr.2017.31
Abstract: Salt-sensitive hypertension is associated with severe organ damage. Generating oxygen radicals is an integral component of salt-induced kidney damage, and activated leukocytes are important in oxygen radical biosynthesis. We hypothesized that a high-salt diet causes… read more here.
Keywords: salt; adhesion; leukocyte adhesion; salt sensitive ... See more keywords
MiR-126 and miR-126* regulate shear-resistant firm leukocyte adhesion to human brain endothelium
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep45284
Abstract: Leukocyte adhesion to brain endothelial cells, the blood-brain barrier main component, is a critical step in the pathogenesis of neuroinflammatory diseases such as multiple sclerosis (MS). Leukocyte adhesion is mediated mainly by selectins, cell adhesion… read more here.
Keywords: mir 126; adhesion; leukocyte adhesion; brain ... See more keywords
Novel FERMT3 and PTPRQ Mutations Associated with Leukocyte Adhesion Deficiency-III and Sensorineural Hearing Loss
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Pediatric Genetics"
DOI: 10.1055/s-0041-1733948
Abstract: Leukocyte adhesion deficiency-III (LAD-III) is a rare genetic disease caused by defective integrin activation in hematopoietic cells due to mutations in the FERMT3 gene. The PTPRQ gene encodes the protein tyrosine phosphatase receptor Q and… read more here.
Keywords: ptprq mutations; hearing loss; sensorineural hearing; deficiency iii ... See more keywords
Genetic Analysis of 13 Iranian Families With Leukocyte Adhesion Deficiency Type 1
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Pediatric Hematology/Oncology"
DOI: 10.1097/mph.0000000000001221
Abstract: Background and Aim: Leukocyte adhesion deficiency type 1 is a rare, autosomal recessive disorder that results from mutations in the ITGB2 gene. This gene encodes the CD18 subunit of &bgr;2 integrin leukocyte adhesion cell molecules.… read more here.
Keywords: leukocyte adhesion; adhesion deficiency; adhesion; deficiency type ... See more keywords
Leukocyte adhesion deficiency type I: A rare primary immunodeficiency disorder
Sign Up to like & getrecommendations! Published in 2017 at "Pediatric Allergy and Immunology"
DOI: 10.1111/pai.12696
Abstract: Leukocyte adhesion deficiency type I (LAD-I) is a rare autosomal recessive primary immunodeficiency disorder that is caused by mutations in ITGB2 gene encoding β2 subunit (CD18) of integrins1. Integrins are required for neutrophils adhesion to… read more here.
Keywords: adhesion; adhesion deficiency; primary immunodeficiency; deficiency type ... See more keywords
Leukocyte adhesion defect‐I: rare primary immune deficiency
Sign Up to like & getrecommendations! Published in 2017 at "Special Care in Dentistry"
DOI: 10.1111/scd.12249
Abstract: Leukocyte adhesion defect I is a rare disorder (1:1,000,000) caused by diminished expression of CD-18 β2 integrins on leukocytes leading to abnormal adhesion, migration, and chemotaxis. Clinical manifestations include delayed separation of umbilical cord, omphalitis,… read more here.
Keywords: defect rare; adhesion; leukocyte adhesion; adhesion defect ... See more keywords
Impaired Treg-DC interactions contribute to autoimmunity in leukocyte adhesion deficiency type 1
Sign Up to like & getrecommendations! Published in 2022 at "JCI Insight"
DOI: 10.1172/jci.insight.162580
Abstract: Leukocyte adhesion deficiency type 1 (LAD-1) is a rare disease resulting from mutations in the gene encoding for the common β-chain of the β2-integrin family (CD18). The most prominent clinical symptoms are profound leukocytosis and… read more here.
Keywords: treg; autoimmunity; leukocyte adhesion; deficiency type ... See more keywords
Leukocyte Adhesion Deficiency-I (LAD-I): A Comprehensive Review of Published Cases
Sign Up to like & getrecommendations! Published in 2017 at "Blood"
DOI: 10.1182/blood.v130.suppl_1.4821.4821
Abstract: LAD-I is a rare disorder of leukocyte adhesion, resulting from ITGB2 gene mutations encoding for the Beta-2 Integrin component CD18. CD18 deficiencies prevent integrin dimerization and endothelial leukocyte adhesion, essential for extravasation and antimicrobial activity.… read more here.
Keywords: lad; cd18; hsct; leukocyte adhesion ... See more keywords
Oleracone F Alleviates Cognitive Impairment and Neuropathology in APPswe/PSEN1dE9 Mice by Reducing the Expression of Vascular Cell Adhesion Molecule and Leukocyte Adhesion to Brain Vascular Endothelial Cells
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24032056
Abstract: Alzheimer’s disease (AD) is the most common neurodegenerative disease and the blood–brain barrier dysfunction has been suggested as a key pathological feature of the disease. Our research group successfully established a synthetic protocol for oleracones,… read more here.
Keywords: adhesion; appswe psen1de9; endothelial cells; brain ... See more keywords