Use of Leukotriene-Receptor Antagonists During Pregnancy and Risk of Neuropsychiatric Events in Offspring
Sign Up to like & getrecommendations! Published in 2023 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2023.1934
Abstract: This cohort study examines the association of the use of leukotriene-receptor antagonists during pregnancy with the risk of neuropsychiatric events in offspring. read more here.
Keywords: pregnancy risk; antagonists pregnancy; risk neuropsychiatric; receptor antagonists ... See more keywords
The leukotriene receptor antagonist montelukast and its possible role in the cardiovascular field
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Clinical Pharmacology"
DOI: 10.1007/s00228-017-2242-2
Abstract: BackgroundCysteinyl leukotrienes (LTC4, LTD4, and LTE4) are pro-inflammatory mediators of the 5-lipooxygenase (5-LO) pathway, that play an important role in bronchoconstriction, but can also enhance endothelial cell permeability and myocardial contractility, and are involved in… read more here.
Keywords: receptor antagonist; leukotriene receptor; antagonist montelukast; role ... See more keywords
Evaluation of oncogenic cysteinyl leukotriene receptor 2 as a therapeutic target for uveal melanoma
Sign Up to like & getrecommendations! Published in 2018 at "Cancer and Metastasis Reviews"
DOI: 10.1007/s10555-018-9751-z
Abstract: Uveal melanoma is a rare, but deadly, form of eye cancer that arises from melanocytes within the uveal tract. Although advances have emerged in treatment of the primary tumour, patients are still faced with vision… read more here.
Keywords: melanoma; cysteinyl leukotriene; leukotriene receptor; uveal melanoma ... See more keywords
The Leukotriene Receptor Antagonist Montelukast Reduces Alpha-Synuclein Load and Restores Memory in an Animal Model of Dementia with Lewy Bodies
Sign Up to like & getrecommendations! Published in 2020 at "Neurotherapeutics"
DOI: 10.1007/s13311-020-00836-3
Abstract: Dementia with Lewy bodies (DLB) represents a huge medical need as it accounts for up to 30% of all dementia cases, and there is no cure available. The underyling spectrum of pathology is complex and… read more here.
Keywords: lewy bodies; dementia lewy; leukotriene receptor; pathology ... See more keywords
Leukotriene receptor expression in mast cells is affected by their agonists.
Sign Up to like & getrecommendations! Published in 2017 at "Cellular immunology"
DOI: 10.1016/j.cellimm.2017.04.010
Abstract: The effects of LTs are mediated by GPCRs: cysLTs interact with CYSLTR1, CYSLTR2, or GPR17, and LTB4 acts via BLT1R or BLT2R. Data relating to the presence of these receptors in mature tissue mast cells… read more here.
Keywords: mast cells; mast; leukotriene receptor; receptor expression ... See more keywords
Development and Characterization of a Fluorescent Ligand for Leukotriene B4 Receptor 2 in Cells and Tissues.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c01589
Abstract: The leukotriene B4 receptor 2 (BLT2) is a G-protein coupled receptor activated by 12(S)-hydroxyheptadeca-5Z,8E,10E-trienoic acid (12-HHT), which has been proposed as a promising therapeutic target for diabetic wound healing and gastrointestinal lesions. In this study,… read more here.
Keywords: development characterization; ligand; fluorescent; receptor ... See more keywords
Leukotriene receptor antagonism may not be effective in atopic dermatitis treatment after all
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Pharmacy and Therapeutics"
DOI: 10.1111/jcpt.12648
Abstract: Literature evidence suggests leukotriene involvement in the pathogenesis of atopic dermatitis. This article aimed to discuss whether the off‐label use of montelukast, a leukotriene receptor antagonist, is justifiable for the treatment of atopic dermatitis. read more here.
Keywords: leukotriene receptor; receptor antagonism; treatment; atopic dermatitis ... See more keywords
Leukotriene Receptor Antagonist Therapy for the Chemoprevention of Human Rectal Aberrant Crypt Foci: Nonrandomized, Open-Label, Controlled Trial.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer prevention research"
DOI: 10.1158/1940-6207.capr-22-0049
Abstract: Leukotriene receptor antagonists (LTRA) are widely used drugs for treating allergic asthma, and they have recently been suggested to have a suppressive effect on carcinogenesis and cancer cell proliferation. Aberrant crypt foci (ACF) are considered… read more here.
Keywords: trial; group; aberrant crypt; chemoprevention ... See more keywords
The efficacy of a leukotriene receptor antagonist in the treatment of human rectal aberrant crypt foci: a nonrandomized, open-label, controlled trial
Sign Up to like & getrecommendations! Published in 2020 at "BMC Cancer"
DOI: 10.1186/s12885-020-07266-6
Abstract: Background Leukotriene receptor antagonists (LTRAs) are broadly used for the management of allergic asthma and have recently been indicated to inhibit carcinogenesis and cancer cell growth. In colorectal cancer (CRC) chemoprevention studies, the occurrence of… read more here.
Keywords: trial; treatment; leukotriene receptor; crypt foci ... See more keywords
The comparative effect of Leukotriene receptor antagonist add on therapy and step up inhaled Corticosteroid in partially controlled asthma: An open-labeled randomized controlled trial.
Sign Up to like & getrecommendations! Published in 2022 at "Allergologia et immunopathologia"
DOI: 10.15586/aei.v50i3.553
Abstract: BACKGROUND No studies are comparing the impact of the add-on leukotriene-receptor antagonist (LTRA) with a step-up dose of inhaled corticosteroids (ICS) in partly controlled asthma patients with asthma control test (ACT) score ˂ 23. OBJECTIVE… read more here.
Keywords: add therapy; step; receptor antagonist; controlled asthma ... See more keywords
Cysteinyl leukotriene receptor 1 facilitates tumorigenesis in a mouse model of colitis-associated colon cancer
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.16718
Abstract: Cysteinyl leukotriene receptor 1 (CysLT1R) has been shown to be up-regulated in the adenocarcinomas of colorectal cancer patients, which is associated with a poor prognosis. In a spontaneous model of colon cancer, CysLT1R disruption was… read more here.
Keywords: cysteinyl leukotriene; leukotriene receptor; colon; model ... See more keywords