Integrated genomic, transcriptomic, and epigenetic analyses identify a leukotriene synthesis-related M2 macrophage gene signature that predicts prognosis and treatment vulnerability in gliomas
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DOI: 10.3389/fimmu.2022.970702
Abstract: The pathological implications of tumor-associated macrophages in the glioma microenvironment have been highlighted, while there lacks a gene signature to characterize the functional status and clinical implications of these cells. Comprehensive bioinformatics approaches were employed… read more here.
Keywords: leukotriene synthesis; synthesis related; gene signature; gene ... See more keywords
Mitochondria-targeted antioxidant SkQ1 inhibits leukotriene synthesis in human neutrophils
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.1023517
Abstract: Leukotrienes are among the most potent mediators of inflammation, and inhibition of their biosynthesis, is becoming increasingly important in the treatment of many pathologies. In this work, we demonstrated that preincubation of human neutrophils with… read more here.
Keywords: human neutrophils; leukotriene synthesis; mitochondria targeted; synthesis ... See more keywords