Probing the impact of temperature and substrates on the conformational dynamics of the Neurotransmitter:Sodium symporter LeuT.
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DOI: 10.1016/j.jmb.2021.167356
Abstract: The crucial function of neurotransmitter:sodium symporters (NSS) in facilitating the reuptake of neurotransmitters into neuronal cells makes them attractive drug targets for treating multiple mental diseases. Due to the challenges in working with eukaryotic NSS… read more here.
Keywords: conformational dynamics; temperature; slow unfolding; leut ... See more keywords