Resculpting the binding pocket of APC superfamily LeuT-fold amino acid transporters
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DOI: 10.1007/s00018-017-2677-8
Abstract: Amino acid transporters are essential components of prokaryote and eukaryote cells, possess distinct physiological functions, and differ markedly in substrate specificity. Amino acid transporters can be both drug targets and drug transporters (bioavailability, targeting) with… read more here.
Keywords: leut fold; acid transporters; apc superfamily; amino acid ... See more keywords
Alternating access mechanisms of LeuT-fold transporters: trailblazing towards the promised energy landscapes.
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DOI: 10.1016/j.sbi.2016.12.006
Abstract: Secondary active transporters couple the uphill translocation of substrates to electrochemical ion gradients. Transporter conformational motion, generically referred to as alternating access, enables a central ligand binding site to change its orientation relative to the… read more here.
Keywords: energy; mechanisms leut; access mechanisms; leut fold ... See more keywords