Streptonigrin Inhibits SENP1 and Reduces the Protein Level of Hypoxia-Inducible Factor 1α (HIF1α) in Cells.
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DOI: 10.1021/acs.biochem.7b00947
Abstract: Streptonigrin (CAS no. 3930-19-6) is a natural product shown to have antitumor activities in clinical trials conducted in the 1960s-1970s. However, its use in clinical studies eventually faded, and the molecular mechanisms of streptonigrin antitumor… read more here.
Keywords: level hypoxia; hif1; inducible factor; hypoxia inducible ... See more keywords