Multi-level inhibition of coronavirus replication by chemical ER stress
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DOI: 10.1038/s41467-021-25551-1
Abstract: Coronaviruses (CoVs) are important human pathogens for which no specific treatment is available. Here, we provide evidence that pharmacological reprogramming of ER stress pathways can be exploited to suppress CoV replication. The ER stress inducer… read more here.
Keywords: cov replication; level inhibition; multi level; coronavirus ... See more keywords
Low-Level Inhibition of Hsp90 Forces Cells to Tip Their (Antigenic) Hand
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DOI: 10.1158/1078-0432.ccr-19-2094
Abstract: Low-level inhibition of hsp90 enhances the antigenicity of cells whereas high-level inhibition diminishes antigenicity. The mechanism(s) by which hsp90 determines antigenicity are only partially clear. Regardless, these observations have profound implications in protein trafficking and… read more here.
Keywords: low level; inhibition hsp90; level inhibition; level ... See more keywords