Tackling Antibiotic Resistance with Systems-Level Perspective.
Sign Up to like & getrecommendations! Published in 2017 at "Cell systems"
DOI: 10.1016/j.cels.2017.12.002
Abstract: Quantitative dissection of regulatory motifs could lead to new ways to fight antibiotic resistance. read more here.
Keywords: resistance systems; level perspective; resistance; antibiotic resistance ... See more keywords
Bacterial persistence from a system-level perspective.
Sign Up to like & getrecommendations! Published in 2017 at "Current opinion in biotechnology"
DOI: 10.1016/j.copbio.2017.02.012
Abstract: In recent years, our understanding about bacterial persistence has significantly advanced: we comprehend the persister phenotype better, more triggers for persistence entry have been found, and more insights in the involvement and role of toxin-antitoxin… read more here.
Keywords: persistence system; system level; level perspective; persistence ... See more keywords
Underground metabolism: network-level perspective and biotechnological potential.
Sign Up to like & getrecommendations! Published in 2018 at "Current opinion in biotechnology"
DOI: 10.1016/j.copbio.2017.07.015
Abstract: A key challenge in molecular systems biology is understanding how new pathways arise during evolution and how to exploit them for biotechnological applications. New pathways in metabolic networks often evolve by recruiting weak promiscuous activities… read more here.
Keywords: underground metabolism; metabolism network; metabolism; level perspective ... See more keywords
Disruption and low-carbon system transformation: Progress and new challenges in socio-technical transitions research and the Multi-Level Perspective
Sign Up to like & getrecommendations! Published in 2017 at "Energy research and social science"
DOI: 10.1016/j.erss.2017.10.010
Abstract: Abstract This paper firstly assesses the usefulness of Christensen’s disruptive innovation framework for low-carbon system change, identifying three conceptual limitations with regard to the unit of analysis (products rather than systems), limited multi-dimensionality, and a… read more here.
Keywords: research; system; carbon system; low carbon ... See more keywords
Conditions for politically accelerated transitions: Historical institutionalism, the multi-level perspective, and two historical case studies in transport and agriculture
Sign Up to like & getrecommendations! Published in 2019 at "Technological Forecasting and Social Change"
DOI: 10.1016/j.techfore.2018.11.019
Abstract: Abstract This article investigates the conditions under which policymakers are likely to decisively accelerate socio-technical transitions. We develop a conceptual framework that combines insights from historical institutionalism and the Multi-Level Perspective to better understand the… read more here.
Keywords: agriculture; case; institutionalism multi; historical institutionalism ... See more keywords
A Community-Level Perspective on Digitally and Socially Including Disabled People
Sign Up to like & getrecommendations! Published in 2017 at "Studies in health technology and informatics"
DOI: 10.3233/978-1-61499-798-6-859
Abstract: A presentation of findings from the evaluation of the Future Digital Inclusion programme funded by the UK Government Department of Education. Data show the effectiveness of embedding digital inclusion support within wider social inclusion services… read more here.
Keywords: disabled people; digitally socially; perspective digitally; level perspective ... See more keywords
An Atomic-Level Perspective of HMG-CoA-Reductase: The Target Enzyme to Treat Hypercholesterolemia
Sign Up to like & getrecommendations! Published in 2020 at "Molecules"
DOI: 10.3390/molecules25173891
Abstract: This review provides an updated atomic-level perspective regarding the enzyme 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoAR), linking the more recent data on this enzyme with a structure/function interpretation. This enzyme catalyzes one of the most important… read more here.
Keywords: atomic level; level perspective; hmg; reductase ... See more keywords