Targeting MDM2 affects spastin protein levels and functions: implications for HSP treatment
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DOI: 10.1038/s41420-025-02333-y
Abstract: Spastin is a microtubule (MT) severing enzyme that regulates several cell functions associated with MT dynamics. A reduction in spastin protein levels is responsible for approximately 40% of cases of Hereditary Spastic Paraplegia (HSP), a… read more here.
Keywords: levels functions; treatment; spastin protein; spastin ... See more keywords