Leveraging the 1,3-azadiene-anhydride reaction for the synthesis of functionalized piperidines bearing up to five contiguous stereocenters
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DOI: 10.1039/d1ra07390g
Abstract: A modular and scalable strategy, which remodels 3-methylglutaric anhydride to 2-oxopiperidines bearing at least three contiguous stereocenters is described. The approach relies on the chemoselective and stereocontrolled annulation of 1,3-azadienes with the anhydride component. The… read more here.
Keywords: leveraging azadiene; reaction synthesis; synthesis functionalized; azadiene anhydride ... See more keywords