Leveraging Peripheral CB1 Antagonism in 1,4,5,6-Tetrahydropyridazine-Based Amidine Substituted Sulfonyl Analogs for Treating Metabolic Disorders.
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DOI: 10.1021/acs.jmedchem.5c01158
Abstract: CB1 receptor antagonists that are peripherally acting hold promise for treating obesity, diabetes and fibrotic disorders highlighting their importance in treating metabolic syndrome disorders (MetS). We synthesized and evaluated compounds by integrating amidine fragments into… read more here.
Keywords: leveraging peripheral; treating metabolic; tetrahydropyridazine based; amidine ... See more keywords