Ascorbic acid can alleviate the degradation of levodopa and carbidopa induced by magnesium oxide
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DOI: 10.1002/brb3.2672
Abstract: Levodopa and carbidopa are reported to be degraded by magnesium oxide (MgO), which is often used as a laxative for patients with Parkinson's disease (PD). Ascorbic acid (AsA) can stabilize levodopa and carbidopa solutions; however,… read more here.
Keywords: levodopa carbidopa; degradation levodopa; ascorbic acid; magnesium oxide ... See more keywords
Problems related to levodopa‐carbidopa intestinal gel treatment in advanced Parkinson's disease
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DOI: 10.1002/brb3.737
Abstract: Continuous levodopa‐carbidopa intestinal gel (LCIG) diminishes daily “off” time and dyskinesia in patients with advanced Parkinson′s disease (PD). Complications are common with percutaneous endoscopic gastrostomy with a jejunal extension tube (PEG‐J). read more here.
Keywords: levodopa carbidopa; carbidopa intestinal; parkinson disease; advanced parkinson ... See more keywords
Levodopa‐Carbidopa Intestinal Gel in a Pediatric Parkinsonism‐plus Syndrome
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DOI: 10.1002/mdc3.12509
Abstract: In Parkinson's disease, levodopa-carbidopa intestinal gel (LCIG) is indicated in control of motor fluctuations, dyskinesias1 and non-motor symptoms. We here report the first case of LCIG pediatric use. Our patient presented with upper limb tremor… read more here.
Keywords: levodopa carbidopa; gel pediatric; carbidopa intestinal; intestinal gel ... See more keywords
Percutaneous Endoscopic Transgastric Jejunostomy (PEG‐J) Tube Placement for Levodopa‐Carbidopa Intrajejunal Gel Therapy in the Interventional Radiology Suite: A Long‐term Follow‐up
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DOI: 10.1002/mdc3.12569
Abstract: Percutaneous endoscopic gastrojejunostomy (PEG) and radiologically inserted gastrojejunostomy (RIG) are both safe and effective techniques for gastrojejunal tube placement. The authors compared these 2 procedures in patients with advanced Parkinson's disease (PD) who required the… read more here.
Keywords: levodopa carbidopa; radiology; percutaneous endoscopic; tube placement ... See more keywords
How Do I Manage Patients With the Levodopa/Carbidopa Intestinal Gel?
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DOI: 10.1002/mdc3.12701
Abstract: The levodopa carbidopa intestinal gel is a device‐assisted therapy used for the management of fluctuating motor symptoms of Parkinson's disease that are refractory to oral therapy. The approach has demonstrable clinical value, but consideration of… read more here.
Keywords: levodopa carbidopa; manage patients; patients levodopa; carbidopa intestinal ... See more keywords
Subthalamic Nucleus Deep Brain Stimulation as Rescue Therapy for Levodopa Carbidopa Intestinal Gel–Associated Biphasic‐Like Dyskinesias
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DOI: 10.1002/mdc3.13277
Abstract: We read with interest the report by Mulroy et al about the patient with Parkinson’s disease (PD) who developed troublesome dyskinesias while on levodopa carbidopa intestinal gel (LCIG) that were successfully treated by adding deep… read more here.
Keywords: levodopa carbidopa; like dyskinesias; biphasic like; lcig ... See more keywords
Population pharmacokinetics of levodopa/carbidopa microtablets in healthy subjects and Parkinson’s disease patients
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DOI: 10.1007/s00228-018-2497-2
Abstract: ObjectivesLow dose, dispersible, levodopa/carbidopa microtablets with an automatic dose dispenser have been developed to facilitate individualized levodopa treatment. The aim of this study was to characterize the pharmacokinetics (PK) of levodopa and carbidopa after microtablet… read more here.
Keywords: levodopa carbidopa; pharmacokinetics levodopa; disease; carbidopa microtablets ... See more keywords
Levodopa–carbidopa intrajejunal infusion in Parkinson’s disease: untangling the role of age
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DOI: 10.1007/s00415-020-10356-x
Abstract: Levodopa–Carbidopa Intrajejunal gel (LCIG) infusion is an effective intervention for people with advanced Parkinson’s disease (PD). Although age may not be a limiting factor for LCIG implant, no data are available on late elderly PD… read more here.
Keywords: levodopa carbidopa; infusion; age; motor ... See more keywords
Levodopa/carbidopa intestinal gel (LCIG) infusion as mono- or combination therapy
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DOI: 10.1007/s00702-017-1698-7
Abstract: Levodopa/carbidopa intestinal gel (LCIG) infusion is an effective escalating therapy in patients with Parkinson disease (PD) suffering from motor fluctuations and dyskinesia. Levodopa/carbidopa given continuously as infusion provides an optimized application of the most effective… read more here.
Keywords: therapy; levodopa carbidopa; lcig infusion; lcig ... See more keywords
Simultaneous and Sensitive Determination of Levodopa and Carbidopa in Pharmaceutical Formulation and Human Serum by High Performance Liquid Chromatography with On-Line Gold Nanoparticles-Catalyzed Luminol Chemiluminescence Detection
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DOI: 10.1016/s1872-2040(17)61021-1
Abstract: Abstract Levodopa, the metabolic precursor of dopamine, is usually administrated in combination with carbidopa to control dopamine levels in an appropriate manner and reduce side effects in the treatment of Parkinson's disease. In this study,… read more here.
Keywords: levodopa carbidopa; gold nanoparticles; line; nanoparticles catalyzed ... See more keywords
Adverse effects of levodopa/carbidopa intrajejunal gel treatment: A single‐center long‐term follow‐up study
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DOI: 10.1111/ane.13675
Abstract: Levodopa/carbidopa intrajejunal gel (LCIG) is an effective therapeutic strategy to overcome levodopa‐induced motor complications in advanced Parkinson's disease (PD). However, it requires invasive percutaneous endoscopic gastrojejunostomy (PEG‐J) and may be associated with serious adverse effects… read more here.
Keywords: long term; intrajejunal gel; levodopa carbidopa; adverse effects ... See more keywords