Pallidal versus subthalamic nucleus deep brain stimulation for levodopa‐induced dyskinesia
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DOI: 10.1002/acn3.50961
Abstract: To compare the efficacy of subthalamic nucleus (STN) and globus pallidus internus (GPi) deep brain stimulation (DBS) on reducing levodopa‐induced dyskinesia (LID) in Parkinson’s disease, and to explore the potential underlying mechanisms. read more here.
Keywords: deep brain; levodopa induced; subthalamic nucleus; induced dyskinesia ... See more keywords
White matter hyperintensities and risk of levodopa‐induced dyskinesia in Parkinson’s disease
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DOI: 10.1002/acn3.50991
Abstract: To investigate whether the burden of white matter hyperintensities (WMHs) is associated with the risk of developing levodopa‐induced dyskinesia (LID) in Parkinson’s disease (PD). read more here.
Keywords: levodopa induced; parkinson disease; induced dyskinesia; matter hyperintensities ... See more keywords
Levodopa‐induced dyskinesia in Parkinson disease: Current and evolving concepts
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DOI: 10.1002/ana.25364
Abstract: Levodopa‐induced dyskinesia is a common complication in Parkinson disease. Pathogenic mechanisms include phasic stimulation of dopamine receptors, nonphysiological levodopa‐to‐dopamine conversion in serotonergic neurons, hyperactivity of corticostriatal glutamatergic transmission, and overstimulation of nicotinic acetylcholine receptors on… read more here.
Keywords: dyskinesia parkinson; levodopa induced; disease; parkinson disease ... See more keywords
Prominent Oromandibular Dystonia as Levodopa‐induced Dyskinesia in Idiopathic Parkinson's Disease
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DOI: 10.1002/mdc3.12759
Abstract: Levodopa-induced dyskinesia (LID) is a recognized motor response complication affecting 30% to 80% of patients with Parkinson’s disease on chronic levodopa (l-dopa) therapy. It is typically choreiform, and involves all parts of the body, especially… read more here.
Keywords: oromandibular dystonia; levodopa induced; parkinson disease;
Randomized, placebo‐controlled trial of ADS‐5102 (amantadine) extended‐release capsules for levodopa‐induced dyskinesia in Parkinson's disease (EASE LID 3)
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DOI: 10.1002/mds.27131
Abstract: The treatment of levodopa‐induced dyskinesia in Parkinson's disease (PD) is an unmet need with no approved drug therapy. read more here.
Keywords: dyskinesia parkinson; induced dyskinesia; levodopa induced; parkinson disease ... See more keywords
Levodopa-induced dyskinesia: clinical features, incidence, and risk factors
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DOI: 10.1007/s00702-018-1900-6
Abstract: Symptoms of Parkinson’s disease have been controlled with levodopa for many years; however, motor complications consisting of wearing off of medication effect and dyskinesias tend to occur within a few years of starting levodopa. Motor… read more here.
Keywords: disease; risk factors; levodopa induced; dyskinesia ... See more keywords
A Web Resource for Levodopa-Induced Dyskinesia Genetics in Parkinson’s Disease
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DOI: 10.1007/s12021-017-9327-z
Abstract: Levodopa-induced dyskinesia (LID) is a side effect of Parkinson’s disease (PD) therapy. The time span from levodopa therapy initiation to the appearance of LID is variable between patients and several publications have investigated a potential… read more here.
Keywords: levodopa; genetics; levodopa induced; web resource ... See more keywords
Pivotal Role of Fyn Kinase in Parkinson's Disease and Levodopa-Induced Dyskinesia: a Novel Therapeutic Target?
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DOI: 10.1007/s12035-020-02201-z
Abstract: The exact etiology of Parkinson's disease (PD) remains obscure, although many cellular mechanisms including α-synuclein aggregation, oxidative damage, excessive neuroinflammation, and dopaminergic neuronal apoptosis are implicated in its pathogenesis. There is still no disease-modifying treatment… read more here.
Keywords: fyn; levodopa induced; role fyn; parkinson disease ... See more keywords
Contralateral levodopa-induced hemichorea in a patient with severe asymmetric Parkinson’s disease
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DOI: 10.1007/s13760-019-01115-5
Abstract: The motor symptoms of Parkinson’s disease (PD) are predominantly due to progressive degeneration of nigral dopaminergic neurons. In most cases, there is a substantial asymmetry of clinical symptoms from disease onset [1]. Such lack of… read more here.
Keywords: hemichorea patient; contralateral levodopa; levodopa induced; disease ... See more keywords
GraphNet-based imaging biomarker model to explain levodopa-induced dyskinesia in Parkinson's disease
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DOI: 10.1016/j.cmpb.2020.105713
Abstract: BACKGROUND AND OBJECTIVE Levodopa-induced dyskinesia (LID) is a disabling complication of Parkinson's disease (PD). Imaging-based measurements, especially those related to the surface shape of the basal ganglia, have shown potential for explaining the severity of… read more here.
Keywords: surface; levodopa induced; model; severity ... See more keywords
Striatal Nurr1, but not FosB expression links a levodopa-induced dyskinesia phenotype to genotype in Fisher 344 vs. Lewis hemiparkinsonian rats
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DOI: 10.1016/j.expneurol.2020.113327
Abstract: Numerous genes, and alterations in their expression, have been identified as risk factors for developing levodopa-induced dyskinesia (LID). However, our understanding of the complexities of molecular changes remains insufficient for development of clinical treatment. In… read more here.
Keywords: levodopa induced; fosb; expression; dyskinesia ... See more keywords