Association Between Generic-to-Generic Levothyroxine Switching and Thyrotropin Levels Among US Adults.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA internal medicine"
DOI: 10.1001/jamainternmed.2022.0045
Abstract: Importance Switching among generic levothyroxine sodium products made by different manufacturers typically occurs at the pharmacy and may affect serum thyrotropin (TSH) levels. Objective To compare TSH levels between patients who continued taking the same… read more here.
Keywords: generic levothyroxine; levothyroxine; tsh level; index date ... See more keywords
Comparative Bioavailability of a Novel Solution and a Tablet Formulation of Levothyroxine
Sign Up to like & getrecommendations! Published in 2023 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.1233
Abstract: Levothyroxine (LT4) is the standard of care for treating hypothyroidism. Despite the established efficacy of LT4, 50% of treated patients fail to achieve normal thyrotropin levels. Oral formulations of LT4 that bypass the gastric phase… read more here.
Keywords: bioavailability novel; tablet; concentration; levothyroxine ... See more keywords
Occurrence of caffeine, fluoxetine, bezafibrate and levothyroxine in surface freshwater of São Paulo State (Brazil) and risk assessment for aquatic life protection
Sign Up to like & getrecommendations! Published in 2021 at "Environmental Science and Pollution Research"
DOI: 10.1007/s11356-020-11799-5
Abstract: The prioritization of active pharmaceutical ingredients (APIs) for monitoring programmes and/or environmental risk assessment (ERA) purposes is based on several criteria, including environmental occurrence data. However, data on API occurrence in Brazilian surface freshwaters are… read more here.
Keywords: risk; surface; occurrence; levothyroxine ... See more keywords
Effect of Levothyroxine on Kidney Function in Chronic Kidney Disease with Subclinical Hypothyroidism in US Veterans: A Retrospective Observational Cohort Study
Sign Up to like & getrecommendations! Published in 2020 at "Advances in Therapy"
DOI: 10.1007/s12325-020-01589-3
Abstract: Chronic kidney disease (CKD) may be associated with overt or subclinical hypothyroidism [SCH; defined as elevated serum thyroid-stimulating hormone (TSH) despite normal free thyroxine levels). Although some studies have demonstrated that thyroid replacement therapy may… read more here.
Keywords: hypothyroidism; chronic kidney; kidney disease; levothyroxine ... See more keywords
Why Were More Than 200 Subjects Required to Demonstrate the Bioequivalence of a New Formulation of Levothyroxine with an Old One?
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Pharmacokinetics"
DOI: 10.1007/s40262-019-00812-x
Abstract: At the request of French Regulatory Authorities, a new formulation of Levothyrox ® was licensed in France in 2017, with the objective of avoiding the stability deficiencies of an existing licensed formulation. Before launching the… read more here.
Keywords: bioequivalence; new formulation; formulation; levothyroxine ... See more keywords
Levothyroxine monotherapy versus levothyroxine and selenium combination therapy in chronic lymphocytic thyroiditis
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Endocrinological Investigation"
DOI: 10.1007/s40618-017-0693-z
Abstract: PurposeNew strategies are needed for prevention and treatment of chronic lymphocytic thyroiditis (CLT). This study aimed to assess whether combination of levothyroxine treatment and selenium (Se) supplementation results in improved therapeutic effects in CLT compared… read more here.
Keywords: combination; levothyroxine monotherapy; levothyroxine selenium; treatment ... See more keywords
Binding interaction of isoxsuprine hydrochloride and levothyroxine to milk β-lactoglobulin; from the perspective of comparison.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2017.12.117
Abstract: Isoxsuprine hydrochloride (ISO) and levothyroxine (LEV) are medicines which can be utilized alone or simultaneously by pregnant women. The purpose of this work is to investigate the separate and simultaneous interaction of ISO and LEV… read more here.
Keywords: iso; isoxsuprine hydrochloride; levothyroxine; lev ... See more keywords
Catalytic activity and structural changes of catalase in the presence of Levothyroxine and Isoxsuprine hydrochloride.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2020.02.064
Abstract: Two drugs that pregnant women (with hypothyroidism) may use during pregnancy include Isoxsuprine hydrochloride (ISO) and levothyroxine (LEV); ISO to reduce uterine contractions and LEV for the treatment of hypothyroidism. In the current work, we… read more here.
Keywords: presence; isoxsuprine hydrochloride; levothyroxine; catalytic activity ... See more keywords
Comparison of Levothyroxine Dosing in Patients with and without Heart Failure
Sign Up to like & getrecommendations! Published in 2019 at "Endocrine Research"
DOI: 10.1080/07435800.2019.1645165
Abstract: ABSTRACT Background: Evidence has shown that low thyroid hormone levels may lead to worse prognosis including a higher mortality rate in patients with heart failure (HF). Thyroid replacement increases cardiac output and exercise performance without… read more here.
Keywords: levothyroxine dosing; levothyroxine; patients without; heart failure ... See more keywords
No Effect of Levothyroxine and Levothyroxine-Induced Subclinical Thyrotoxicosis on the Pharmacokinetics of Sorafenib in Healthy Male Subjects
Sign Up to like & getrecommendations! Published in 2017 at "Thyroid"
DOI: 10.1089/thy.2017.0085
Abstract: Background: Patients receiving the multikinase inhibitor sorafenib for locally recurrent or metastatic, progressive, differentiated thyroid carcinoma (DTC) refractory to radioactive iodine often receive concomitant levothyroxine for thyrotropin (TSH) suppression. In the Phase 3 DTC trial… read more here.
Keywords: levothyroxine induced; sorafenib; levothyroxine; subclinical thyrotoxicosis ... See more keywords
In Vivo Evaluation of the Pharmacokinetic Interaction between Levothyroxine and Amiodarone in Rat Plasma: Evaluation of Importance of Therapeutic Drug Monitoring during Co-Therapy.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of chromatographic science"
DOI: 10.1093/chromsci/bmad034
Abstract: Amiodarone-induced thyrotoxicosis (AIT) is a common condition in patients who are receiving amiodarone for cardiac arrhythmia. This risk is elevated in iodine-deficient regions. Levothyroxine is the standard treatment for patients with hypothyroidism. This investigation is… read more here.
Keywords: evaluation; pharmacokinetic interaction; rat plasma; levothyroxine ... See more keywords