Glycan Stability and Flexibility: Thermodynamic and Kinetic Characterization of Nonconventional Hydrogen Bonding in Lewis Antigens
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c13104
Abstract: We provide evidence for CH-based nonconventional hydrogen bonds (H-bonds) for 10 Lewis antigens and two of their rhamnose analogues. We also characterize the thermodynamics and kinetics of the H-bonds in these molecules and present a… read more here.
Keywords: flexibility thermodynamic; lewis antigens; stability flexibility; glycan stability ... See more keywords
Synthesis of the H-type 1 and Lewis B antigens as 6-aminohexyl glycosides.
Sign Up to like & getrecommendations! Published in 2024 at "Canadian Journal of Chemistry"
DOI: 10.1139/cjc-2024-0071
Abstract: The LebLea heptasaccharide is a TACA that was isolated from the human colonic adenocarcinoma cell line Colo205 and is a good target for the development of anti-cancer immunotherapeutics. However, it displays on its reducing end… read more here.
Keywords: type lewis; lewis antigens; synthesis type; aminohexyl glycosides ... See more keywords
Synthesis of Type-I and Type-II LacNAc-Repeating Oligosaccharides as the Backbones of Tumor-Associated Lewis Antigens
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.858894
Abstract: Type-I and Type-II LacNAc are Gal-GlcNAc disaccharides bearing a β1,3- or β1,4-linkage respectively. They exist as the backbones of Lewis antigens that are highly expressed in several cancers. Owing to the promise of developing carbohydrate-based… read more here.
Keywords: type type; synthesis type; lewis antigens; synthesis ... See more keywords