EXT418, a novel long‐acting ghrelin, mitigates Lewis lung carcinoma induced cachexia in mice
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Cachexia, Sarcopenia and Muscle"
DOI: 10.1002/jcsm.13211
Abstract: Ghrelin is a potential therapy for cachexia due to its orexigenic properties and anabolic effects on muscle and fat. However, its clinical use is limited by the short half‐life of active (acylated) ghrelin (~11 min… read more here.
Keywords: lung carcinoma; ext418 novel; novel long; lewis lung ... See more keywords
Cryptotanshinone has curative dual anti-proliferative and immunotherapeutic effects on mouse Lewis lung carcinoma
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Immunology, Immunotherapy"
DOI: 10.1007/s00262-019-02326-8
Abstract: Lung cancer is currently the leading cause of cancer-related mortality with very limited effective therapy. Screening of a variety of traditional Chinese medicines (TCMs) for their capacity to inhibit the proliferation of human lung cancer… read more here.
Keywords: llc; lung carcinoma; lewis lung; cancer ... See more keywords
Synthetic Phenolic Antioxidant TS-13 Suppresses the Growth of Lewis Lung Carcinoma and Potentiates Oncolytic Effect of Doxorubicin
Sign Up to like & getrecommendations! Published in 2019 at "Bulletin of Experimental Biology and Medicine"
DOI: 10.1007/s10517-019-04410-6
Abstract: ROS are important intracellular messengers; their ambiguous role in malignant processes was demonstrated in many studies. The effects of a synthetic phenolic antioxidant sodium 3-(3’-tert-butyl-4’-hydroxyphenyl)propyl thiosulfonate sodium (TS-13) on the tumor growth and oncolytic properties… read more here.
Keywords: synthetic phenolic; lung carcinoma; lewis lung; doxorubicin ... See more keywords
Specific overexpression of 15-lipoxygenase in endothelial cells promotes cancer cell death in an in vivo Lewis lung carcinoma mouse model.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in medical sciences"
DOI: 10.1016/j.advms.2019.11.006
Abstract: PURPOSE Lipoxygenases (LOX) have been implicated in carcinogenesis, however both pro- and anti-carcinogenic effects have been reported in different cancer models. Using transgenic mice, which specifically overexpress human 15-lipoxygenase (ALOX15) in endothelial cells (EC), we… read more here.
Keywords: overexpression; model; lewis lung; endothelial cells ... See more keywords
Effect of tetramethylpyrazine combined with cisplatin on VEGF, KLF4 and ADAMTS1 in Lewis lung cancer mice.
Sign Up to like & getrecommendations! Published in 2017 at "Asian Pacific journal of tropical medicine"
DOI: 10.1016/j.apjtm.2017.08.001
Abstract: OBJECTIVE To further explore the function of combine use of tetramethylpyrazine (TMP) and cisplatin (DDP) in lung carcinoma. METHODS We used the combination drug to treat Lewis lung cancer mice, investigated the expression level of… read more here.
Keywords: klf4 adamts1; lewis lung; lung cancer; lung ... See more keywords
The Chinese medicine JC-001 enhances the chemosensitivity of Lewis lung tumors to cisplatin by modulating the immune response
Sign Up to like & getrecommendations! Published in 2017 at "BMC Complementary and Alternative Medicine"
DOI: 10.1186/s12906-017-1728-x
Abstract: BackgroundJC-001 is a Chinese medicine that can modulate the immunity in Hepa 1-6 tumor-bearing mice, and we questioned whether JC-001 can serve as efficient adjuvant chemotherapy. We aimed to identify a novel approach for enhancing… read more here.
Keywords: medicine; response; chinese medicine; lewis lung ... See more keywords
Heterogeneity of circulating tumor cell dissemination and lung metastases in a subcutaneous Lewis lung carcinoma model.
Sign Up to like & getrecommendations! Published in 2020 at "Biomedical optics express"
DOI: 10.1364/boe.395289
Abstract: Subcutaneous (s.c.) tumor models are widely used in pre-clinical cancer metastasis research. Despite this, the dynamics and natural progression of circulating tumor cells (CTCs) and CTC clusters (CTCCs) in peripheral blood are poorly understood in… read more here.
Keywords: lung metastases; lung; circulating tumor; lewis lung ... See more keywords
Impact of lactic acidosis on the survival of Lewis lung carcinoma cells.
Sign Up to like & getrecommendations! Published in 2017 at "Experimental oncology"
DOI: 10.31768/2312-8852.2017.39(2):112-116
Abstract: AIM To investigate the effect of lactic acidosis on the survival of Lewis lung carcinoma cells under glucose-deprived conditions. MATERIALS AND METHODS LLC/R9 variant of Lewis lung carcinoma cells was cultured in glucose deficit or complete… read more here.
Keywords: acidosis; lactic acidosis; lung carcinoma; lewis lung ... See more keywords
Cell Therapy with Human Reprogrammed CD8+ T-Cells Has Antimetastatic Effects on Lewis Lung Carcinoma in C57BL/6 Mice
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232415780
Abstract: Using a model of Lewis lung carcinoma (LLC) in vitro and in vivo, we previously demonstrated increased antitumor activity in CD8+ T-cells reprogrammed with an MEK inhibitor and PD-1 blocker. In this follow-up study, we… read more here.
Keywords: lung carcinoma; cell therapy; lewis lung; lung ... See more keywords
D-allose enhances the efficacy of hydroxychloroquine against Lewis lung carcinoma cell growth by inducing autophagy
Sign Up to like & getrecommendations! Published in 2022 at "Oncology Reports"
DOI: 10.3892/or.2022.8328
Abstract: Various cancer cells require massive amounts of glucose as an energy source for their dysregulated growth. Although D-allose, a rare sugar, inhibits tumor cell growth via inhibition of glucose uptake, a few cells can survive… read more here.
Keywords: cell; growth; cell growth; lewis lung ... See more keywords