Association of Longitudinal β-Amyloid Accumulation Determined by Positron Emission Tomography With Clinical and Cognitive Decline in Adults With Probable Lewy Body Dementia
Sign Up to like & getrecommendations! Published in 2019 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2019.16439
Abstract: Key Points Question What is the trajectory of β-amyloid accumulation over time, and how is it associated with clinical and cognitive decline among patients with probable dementia with Lewy bodies? Findings This cohort study of… read more here.
Keywords: lewy bodies; dementia lewy; accumulation; amyloid accumulation ... See more keywords
Translocator protein in late stage Alzheimer’s disease and Dementia with Lewy bodies brains
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.50837
Abstract: Increased translocator protein (TSPO), previously known as the peripheral benzodiazepine receptor (PBR), in glial cells of the brain has been used as a neuroinflammation marker in the early and middle stages of neurodegenerative diseases, such… read more here.
Keywords: lewy bodies; dementia lewy; late stage; alzheimer disease ... See more keywords
Gender difference in the association and presentation of visual hallucinations in dementia with Lewy bodies: a cross‐sectional study
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Geriatric Psychiatry"
DOI: 10.1002/gps.4706
Abstract: Visual hallucinations (VHs) are among the most striking features of dementia with Lewy bodies (DLB). We investigated gender differences in the association and presentation of VHs in DLB. read more here.
Keywords: lewy bodies; dementia lewy; visual hallucinations; association presentation ... See more keywords
Blood pressure and heart rate responses to orthostatic challenge and Valsalva manoeuvre in mild cognitive impairment with Lewy bodies
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Geriatric Psychiatry"
DOI: 10.1002/gps.5709
Abstract: Orthostatic hypotension is a common feature of normal ageing, and age‐related neurodegenerative diseases, in particular the synucleinopathies including dementia with Lewy bodies. Orthostatic hypotension and other abnormal cardiovascular responses may be early markers of Lewy… read more here.
Keywords: rate responses; heart rate; blood pressure; lewy ... See more keywords
Electroconvulsive therapy improves psychotic symptoms in patients with dementia with Lewy bodies
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DOI: 10.1002/gps.5832
Abstract: The aim of this study was to examine the efficacy and safety of electroconvulsive therapy (ECT) for psychotic symptoms of dementia with Lewy bodies (DLB), and also to determine its use as an adaptive criterion. read more here.
Keywords: dementia lewy; therapy improves; psychotic symptoms; lewy bodies ... See more keywords
Autonomic dysfunction in genetic forms of synucleinopathies
Sign Up to like & getrecommendations! Published in 2018 at "Movement Disorders"
DOI: 10.1002/mds.27343
Abstract: The discovery of genetic links between alpha‐synuclein and PD has opened unprecedented opportunities for research into a new group of diseases, now collectively known as synucleinopathies. Autonomic dysfunction, including cardiac sympathetic denervation, has been reported… read more here.
Keywords: lewy bodies; dysfunction genetic; dysfunction; forms synucleinopathies ... See more keywords
Clinical and imaging correlates of amyloid deposition in dementia with Lewy bodies
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DOI: 10.1002/mds.27403
Abstract: Background: Amyloid deposition is common in dementia with Lewy bodies, but its pathophysiological significance is unclear. read more here.
Keywords: lewy bodies; clinical imaging; dementia lewy; amyloid deposition ... See more keywords
Prodromal Dementia With Lewy Bodies: Clinical Characterization and Predictors of Progression
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DOI: 10.1002/mds.27997
Abstract: The objective of this study was to examine clinical characteristics, cognitive decline, and predictors for time to dementia in prodromal dementia with Lewy bodies with mild cognitive impairment (MCI‐LB) compared with prodromal Alzheimer's disease (MCI‐AD). read more here.
Keywords: lewy bodies; dementia lewy; dementia; prodromal dementia ... See more keywords
Nilotinib Fails to Prevent Synucleinopathy and Cell Loss in a Mouse Model of Multiple System Atrophy
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DOI: 10.1002/mds.28034
Abstract: Multiple system atrophy (MSA) is a rare, untreatable neurodegenerative disorder characterized by accumulation of α‐synuclein in oligodendroglial inclusions. As such, MSA is a synucleinopathy along with Parkinson's disease (PD) and dementia with Lewy bodies. Activation… read more here.
Keywords: lewy bodies; multiple system; system atrophy; dementia lewy ... See more keywords
A Longitudinal Study of Plasma pTau181 in Mild Cognitive Impairment with Lewy Bodies and Alzheimer's Disease
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DOI: 10.1002/mds.28994
Abstract: Alzheimer's disease (AD) co‐pathology is common in dementia with Lewy bodies and is associated with increased decline. Plasma pTau181 is a blood‐based biomarker that can detect AD co‐pathology. read more here.
Keywords: pathology; alzheimer disease; lewy bodies; plasma ptau181 ... See more keywords
(Dis‐)Connected Dots in Dementia with Lewy Bodies—A Systematic Review of Connectivity Studies
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DOI: 10.1002/mds.29248
Abstract: Studies on dementia with Lewy bodies (DLB) have mainly focused on the degeneration of distinct cortical and subcortical regions related to the deposition of Lewy bodies. In view of the proposed trans‐synaptic spread of the… read more here.
Keywords: connectivity; brain; systematic review; pathology ... See more keywords