Dysregulation of 14‐3‐3 proteins in neurodegenerative diseases with Lewy body or Alzheimer pathology
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DOI: 10.1002/acn3.421
Abstract: The highly conserved 14‐3‐3 proteins interact with key players involved in Parkinson's disease (PD) and other neurodegenerative disorders. We recently demonstrated that 14‐3‐3 phosphorylation is increased in PD models and that increased 14‐3‐3 phosphorylation reduces… read more here.
Keywords: diseases lewy; dysregulation proteins; neurodegenerative diseases; pathology ... See more keywords
Cardioselective peripheral noradrenergic deficiency in Lewy body synucleinopathies
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DOI: 10.1002/acn3.51243
Abstract: Lewy body (LB) synucleinopathies such as Parkinson’s disease (PD) entail profound cardiac norepinephrine deficiency. The status of sympathetic noradrenergic innervation at other extracranial sites has been unclear. Although in vivo neuroimaging studies have indicated a… read more here.
Keywords: body synucleinopathies; cardioselective peripheral; deficiency; lewy body ... See more keywords
Quantifying regional α ‐synuclein, amyloid β, and tau accumulation in lewy body dementia
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DOI: 10.1002/acn3.51482
Abstract: Parkinson disease (PD) is defined by the accumulation of misfolded α‐synuclein (α‐syn) in Lewy bodies and Lewy neurites. It affects multiple cortical and subcortical neuronal populations. The majority of people with PD develop dementia, which… read more here.
Keywords: body dementia; tau accumulation; accumulation; amyloid tau ... See more keywords
Reply to “Pure autonomic failure vs. Manifest CNS synucleinopathy: Relevance of stridor and autonomic biomarkers”
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DOI: 10.1002/ana.24949
Abstract: We read with interest the excellent seminal study of Kaufmann et al demonstrating the natural history of pure autonomic failure (PAF). We offer the following comments. The authors found several distinguishing features predicting whether the… read more here.
Keywords: autonomic failure; stridor; lewy body; body disease ... See more keywords
Depression and Nigral Neuron Density in Lewy Body Spectrum Diseases
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DOI: 10.1002/ana.26046
Abstract: Parkinson's disease and other Lewy body spectrum diseases (LBDs) are associated with a specific risk for clinical depression. In the present clinicopathological study with 73 patients with LBD, we observed that the substantia nigra pars… read more here.
Keywords: spectrum diseases; body spectrum; neuron density; lewy body ... See more keywords
Effects of Alzheimer and Lewy Body Disease Pathologies on Brain Metabolism
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DOI: 10.1002/ana.26355
Abstract: This study aimed to determine the pattern of 18F‐fluorodeoxyglucose positron emission tomography (FDG‐PET) related to postmortem Lewy body disease (LBD) pathology in clinical Alzheimer disease (AD). read more here.
Keywords: disease; effects alzheimer; body disease; alzheimer lewy ... See more keywords
Illusory Responses across the Lewy Body Disease Spectrum
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DOI: 10.1002/ana.26574
Abstract: This study was undertaken to study pareidolias, or perceived meaningful objects in a meaningless stimulus, in patients across the Lewy body (LB) disease spectrum, where most do not report hallucinations or delusions. read more here.
Keywords: body disease; across lewy; lewy body; disease spectrum ... See more keywords
Structural connectivity networks in Alzheimer’s disease and Lewy body disease
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DOI: 10.1002/brb3.2112
Abstract: We evaluated disruption of the white matter (WM) network related with Alzheimer's disease (AD) and Lewy body disease (LBD), which includes Parkinson's disease and dementia with Lewy bodies. read more here.
Keywords: disease lewy; alzheimer disease; disease; body disease ... See more keywords
Genetic association between RAGE polymorphisms and Alzheimer's disease and Lewy body dementias in a Japanese cohort: a case–control study
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DOI: 10.1002/gps.4600
Abstract: Interaction of receptor for advanced glycation end products (RAGE) with amyloid‐β increases amplification of oxidative stress and plays pathological roles in Alzheimer's disease (AD). Oxidative stress leads to α‐synuclein aggregation and is also a major… read more here.
Keywords: alzheimer disease; lewy body; body dementias;
Effect of biological treatments on psychotic symptoms in lewy body disease: A systematic review and meta‐analysis of randomized controlled trials
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DOI: 10.1002/gps.5376
Abstract: Parkinson disease and dementia with Lewy bodies (collectively termed Lewy body disease) are common neurodegenerative conditions of later life and are frequently associated with distressing psychotic symptoms. The best approach to manage these symptoms is… read more here.
Keywords: disease; body disease; psychotic symptoms; effect biological ... See more keywords
Psychometric properties of the Autonomic Symptoms Checklist in the Lewy body disease module of the uniform dataset
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DOI: 10.1002/gps.5838
Abstract: Autonomic dysfunction is an important feature of Lewy Body Dementia (DLB), but measurement of autonomic symptoms has been limited in both previous research and clinical practice. Accurate measurement of autonomic dysfunction has the potential to… read more here.
Keywords: psychometric properties; properties autonomic; lewy body; module ... See more keywords