PDGF‐AA activates AKT and ERK signaling for testicular interstitial Leydig cell growth via primary cilia
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.30345
Abstract: Testes control the development of male reproductive system. The testicular interstitial Leydig cells (Leydig cells) synthesize testosterone for promoting spermatogenesis and secondary sexual characteristics. Type A platelet‐derived growth factor (PDGF‐AA) is one of the most… read more here.
Keywords: growth; leydig; leydig cell; akt erk ... See more keywords
Brain‐derived neurotrophic factor: A steroidogenic regulator of Leydig cells
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28095
Abstract: The brain‐derived neurotrophic factor (BDNF) was first recognized for its roles in the peripheral and central nervous systems, and its complex functions on mammalian organs have been extended constantly. However, to date, little is known… read more here.
Keywords: brain derived; derived neurotrophic; tm3 leydig; leydig ... See more keywords
Tetramethyl bisphenol A stimulates proliferation but inhibits fetal Leydig cell function in male rats by targeting estrogen receptor α after in utero exposure
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Toxicology"
DOI: 10.1002/tox.23633
Abstract: Tetramethyl bisphenol A (TMBPA) is a widely used flame retardant. TMBPA has been a toxic to Leydig cells in puberty, but it remains unclear whether TMBPA has a similar inhibitor effect on fetal Leydig cells… read more here.
Keywords: utero exposure; leydig; fetal leydig; tmbpa ... See more keywords
Effects of Fluoride on Surface Structure of Primary Culture Leydig Cells in Mouse
Sign Up to like & getrecommendations! Published in 2017 at "Biological Trace Element Research"
DOI: 10.1007/s12011-017-1121-0
Abstract: Fluoride (F) is known to induce reproduction toxicity, and the elucidation of its underlying mechanisms is an ongoing research. These findings aim to provide deeper insights into roles of soduim fluoride (NaF) in testis damage,… read more here.
Keywords: effects fluoride; leydig; leydig cells; surface structure ... See more keywords
Paraquat exposure delays stem/progenitor Leydig cell regeneration in the adult rat testis.
Sign Up to like & getrecommendations! Published in 2019 at "Chemosphere"
DOI: 10.1016/j.chemosphere.2019.05.104
Abstract: Paraquat, a widely used nonselective herbicide, is a serious hazard to human health. However, the effects of paraquat on the male reproductive system remain unclear. In this study, adult male Sprague Dawley rats were intraperitoneally… read more here.
Keywords: leydig cell; adult; paraquat; leydig ... See more keywords
BMAL1 knockdown promoted apoptosis and reduced testosterone secretion in TM3 Leydig cell line.
Sign Up to like & getrecommendations! Published in 2020 at "Gene"
DOI: 10.1016/j.gene.2020.144672
Abstract: Brain and muscle Arnt-like protein-1 (BMAL1) is a clock gene that plays an important role in hormone secretion and apoptosis, but its effect on Leydig cells is unidentified. Here the role of BMAL1 in apoptosis… read more here.
Keywords: secretion; apoptosis; testosterone secretion; leydig ... See more keywords
Bilateral congenital cryptorchidism and unilateral Leydig cell tumor in an adult presenting with gynecomastia and primary infertility: A case report
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Surgery Case Reports"
DOI: 10.1016/j.ijscr.2022.106923
Abstract: Introduction and importance The neoplasms of the testis are sporadic tumors among men. Furthermore, the rarest subset of these is neoplasms belonging to the stromal tumors of the sex cord. Leydig cell tumors are the… read more here.
Keywords: cryptorchidism; leydig; cell tumor; case ... See more keywords
Leydig progenitor cells in fetal testis
Sign Up to like & getrecommendations! Published in 2017 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2016.12.006
Abstract: Testicular Leydig cells play pivotal roles in masculinization of organisms by producing androgens. At least two distinct Leydig cell populations sequentially emerge in the mammalian testis. Leydig cells in the fetal testis (fetal Leydig cells)… read more here.
Keywords: testis; fetal leydig; adult leydig; leydig ... See more keywords
Short-term exposure to perfluorotetradecanoic acid affects the late-stage regeneration of Leydig cells in adult male rats.
Sign Up to like & getrecommendations! Published in 2021 at "Toxicology and applied pharmacology"
DOI: 10.1016/j.taap.2021.115777
Abstract: Perfluorotetradecanoic acid (PFTeDA) is one of perfluoroalkyl substances widely found in the environment. PFTeDA may cause the dysfunction of male reproductive system. However, whether PFTeDA affects the regeneration of Leydig cells remains unclear. The objective… read more here.
Keywords: late stage; pfteda; regeneration; leydig ... See more keywords
Icariin promotes mouse Leydig cell testosterone synthesis via the Esr1/Src/Akt/Creb/Sf-1 pathway.
Sign Up to like & getrecommendations! Published in 2022 at "Toxicology and applied pharmacology"
DOI: 10.1016/j.taap.2022.115969
Abstract: Icariin (ICA), extracted from Epimedium, is a flavonoid used in traditional Chinese medicine. Di(2-ethylhexyl) phthalate (DEHP) is a phthalate used in commercial products as a plasticizer that can influence the human endocrine and reproduction system.… read more here.
Keywords: testosterone synthesis; akt creb; leydig; creb ... See more keywords
Low Dose of Fire Retardant, 2,2',4,4'-Tetrabromodiphenyl ether (BDE47), stimulates the proliferation and differentiation of progenitor Leydig cells of male rats during prepuberty.
Sign Up to like & getrecommendations! Published in 2021 at "Toxicology letters"
DOI: 10.1016/j.toxlet.2021.02.006
Abstract: 2,2',4,4'-Tetrabromodiphenyl ether (BDE47), a flame retardant, is extensively distributed in the food chain. However, whether BDE47 affects Leydig cell development during prepuberty remains unclear. BDE47 was daily gavaged to 21-day-old Sprague-Dawley male rats with 0… read more here.
Keywords: male rats; tetrabromodiphenyl ether; ether bde47; leydig ... See more keywords