PDGF‐AA activates AKT and ERK signaling for testicular interstitial Leydig cell growth via primary cilia
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.30345
Abstract: Testes control the development of male reproductive system. The testicular interstitial Leydig cells (Leydig cells) synthesize testosterone for promoting spermatogenesis and secondary sexual characteristics. Type A platelet‐derived growth factor (PDGF‐AA) is one of the most… read more here.
Keywords: growth; leydig; leydig cell; akt erk ... See more keywords
Cypermethrin inhibits Leydig cell development and function in pubertal rats
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Toxicology"
DOI: 10.1002/tox.23473
Abstract: Cypermethrin is a broad‐spectrum pyrethroid insecticide that is widely used. It may induce adverse endocrine‐disrupting effects on the male reproductive system. Whether cypermethrin can disrupt Leydig cell development and function in the late puberty remains… read more here.
Keywords: leydig cell; cell; development function; cypermethrin ... See more keywords
In utero single low-dose exposure of cadmium induces rat fetal Leydig cell dysfunction.
Sign Up to like & getrecommendations! Published in 2018 at "Chemosphere"
DOI: 10.1016/j.chemosphere.2017.11.159
Abstract: Cadmium chloride (Cd) is a potent endocrine disruptor and may cause the malformation in the male reproductive tract. However, the effects of a single in utero exposure to low doses of Cd on fetal Leydig… read more here.
Keywords: leydig cell; rat fetal; fetal leydig; exposure ... See more keywords
Paraquat exposure delays stem/progenitor Leydig cell regeneration in the adult rat testis.
Sign Up to like & getrecommendations! Published in 2019 at "Chemosphere"
DOI: 10.1016/j.chemosphere.2019.05.104
Abstract: Paraquat, a widely used nonselective herbicide, is a serious hazard to human health. However, the effects of paraquat on the male reproductive system remain unclear. In this study, adult male Sprague Dawley rats were intraperitoneally… read more here.
Keywords: leydig cell; adult; paraquat; leydig ... See more keywords
Exposure to di-n-octyl phthalate during puberty induces hypergonadotropic hypogonadism caused by Leydig cell hyperplasia but reduced steroidogenic function in male rats.
Sign Up to like & getrecommendations! Published in 2020 at "Ecotoxicology and environmental safety"
DOI: 10.1016/j.ecoenv.2020.111432
Abstract: Humans are exposed to phthalates ubiquitously, which may threaten health. However, whether di-n-octyl phthalate can prevent pubertal sexual maturity is still elusive. In this study, male Sprague Dawley rats (age 35 days) were treated daily… read more here.
Keywords: leydig cell; phthalate; octyl phthalate; cell hyperplasia ... See more keywords
Tetramethyl bisphenol a inhibits leydig cell function in late puberty by inducing ferroptosis.
Sign Up to like & getrecommendations! Published in 2022 at "Ecotoxicology and environmental safety"
DOI: 10.1016/j.ecoenv.2022.113515
Abstract: Tetramethyl bisphenol A (TMBPA) is a commonly used bisphenol analog, used as a fire retardant. However, whether it inhibits the function of Leydig cells in late puberty remains unclear. In this study, 35-day-old male Sprague-Dawley… read more here.
Keywords: leydig cell; bisphenol; late puberty; leydig cells ... See more keywords
Incidental Leydig Cell Tumor in Patient with Hormone Resistant Prostate Cancer
Sign Up to like & getrecommendations! Published in 2017 at "Urology Case Reports"
DOI: 10.1016/j.eucr.2017.03.027
Abstract: We hereby present the case of a 55 years old patient with clinical diagnosis of high-risk prostate cancer T2bN1Mo Gleason 9 (4 + 5) treated with androgen deprivation therapy and external beam radiotherapy. Despite treatment,… read more here.
Keywords: leydig cell; incidental leydig; cell tumor; prostate cancer ... See more keywords
Testicular leydig cell tumor revealed by hydrocele
Sign Up to like & getrecommendations! Published in 2021 at "Urology Case Reports"
DOI: 10.1016/j.eucr.2020.101520
Abstract: Leydig cell tumor (LCT) is a rare testicular tumor with a low incidence accounting 3% of all testicule neoplasms. Due to its rarity, the natural history of LCT is poorly understood. Patients can present with… read more here.
Keywords: leydig cell; testicular leydig; cell tumor; tumor ... See more keywords
Poorly differentiated, ovarian Sertoli-Leydig cell tumor with heterologous rhabdomyosarcoma and glandular elements: Diagnosis and management of a rare neoplasm
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DOI: 10.1016/j.gore.2018.06.003
Abstract: Ovarian Sertoli-Leydig cell tumors (SLCT) represent read more here.
Keywords: leydig cell; sertoli leydig; ovarian sertoli; poorly differentiated ... See more keywords
An inguinal hernia with cryptorchidism with a Leydig cell tumor in an elderly man: A case report
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Surgery Case Reports"
DOI: 10.1016/j.ijscr.2017.01.048
Abstract: Highlights • Laparoscopy was helpful for the unusual inguinal hernia with cryptorchidism.• The resected ectopic testis in elderly man contained a Leydig cell tumor.• Cryptorchidism may predispose to the development of a Leydig cell tumor.•… read more here.
Keywords: leydig cell; cryptorchidism; cell tumor; inguinal hernia ... See more keywords
Bilateral congenital cryptorchidism and unilateral Leydig cell tumor in an adult presenting with gynecomastia and primary infertility: A case report
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Surgery Case Reports"
DOI: 10.1016/j.ijscr.2022.106923
Abstract: Introduction and importance The neoplasms of the testis are sporadic tumors among men. Furthermore, the rarest subset of these is neoplasms belonging to the stromal tumors of the sex cord. Leydig cell tumors are the… read more here.
Keywords: cryptorchidism; leydig; cell tumor; case ... See more keywords