Brain‐derived neurotrophic factor: A steroidogenic regulator of Leydig cells
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28095
Abstract: The brain‐derived neurotrophic factor (BDNF) was first recognized for its roles in the peripheral and central nervous systems, and its complex functions on mammalian organs have been extended constantly. However, to date, little is known… read more here.
Keywords: brain derived; derived neurotrophic; tm3 leydig; leydig ... See more keywords
CREBZF regulates testosterone production in mouse Leydig cells
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28846
Abstract: CREBZF, including the two isoforms SMILE (long isoform of CREBZF) and Zhangfei (short isoform of CREBZF), has been identified as a novel transcriptional coregulator of a variety of nuclear receptors. Our previous studies found that… read more here.
Keywords: crebzf; testosterone production; expression; leydig cells ... See more keywords
The differential role of Leydig cells in the skin and gills of Lissotriton italicus larvae
Sign Up to like & getrecommendations! Published in 2022 at "Microscopy Research and Technique"
DOI: 10.1002/jemt.24068
Abstract: Larval urodeles are provided with external gills involved, along with the skin, in gas exchange and osmoregulation. Gills and skin epithelia are different, each showing a peculiar set of specialized cells but both provided with… read more here.
Keywords: lissotriton italicus; skin gills; gills lissotriton; leydig cells ... See more keywords
Multi‐ and transgenerational biochemical effects of low‐dose exposure to bisphenol A and 4‐nonylphenol on testicular interstitial (Leydig) cells
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Toxicology"
DOI: 10.1002/tox.23462
Abstract: Bisphenol A (BPA) and 4‐nonylphenol (NP) are well‐known endocrine‐disrupting chemicals (EDCs) that have been proven to affect Leydig cell (LC) functions and testosterone production, but whether BPA and NP have multi‐ and transgenerational biochemical effects… read more here.
Keywords: leydig cells; bpa; transgenerational biochemical; multi transgenerational ... See more keywords
Role of autophagy in lysophosphatidylcholine‐induced apoptosis in mouse Leydig cells
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Toxicology"
DOI: 10.1002/tox.23634
Abstract: Lysophosphatidylcholine (LPC), a major class of glycerophospholipids ubiquitously present in most tissues, plays a dominant role in many diseases, while it is still unknown about the potential mechanism of LPC affecting the testicular Leydig cells.… read more here.
Keywords: apoptosis; leydig cells; mouse; lpc ... See more keywords
Selenium nanoparticles improve nickel-induced testosterone synthesis disturbance by down-regulating miR-708-5p/p38 MAPK pathway in Leydig cells.
Sign Up to like & getrecommendations! Published in 2023 at "Environmental toxicology"
DOI: 10.1002/tox.23811
Abstract: The present study was designed to investigate the role of miR-708-5p/p38 mitogen-activated protein kinase (MAPK) pathway during the mechanism of selenium nanoparticles (Nano-Se) against nickel (Ni)-induced testosterone synthesis disorder in rat Leydig cells. We conducted… read more here.
Keywords: mir 708; leydig cells; p38 mapk; testosterone synthesis ... See more keywords
Corticosteroid-binding globulin, induced in testicular Leydig cells by perfluorooctanoic acid, promotes steroid hormone synthesis
Sign Up to like & getrecommendations! Published in 2018 at "Archives of Toxicology"
DOI: 10.1007/s00204-018-2207-y
Abstract: Perfluorooctanoic acid (PFOA) is an abundant perfluoroalkyl substance widely applied in industrial and consumer products. It is a ubiquitous environmental pollutant and suspected endocrine disruptor. Corticosteroid-binding globulin (CBG) is a monomeric glycoprotein that can bind… read more here.
Keywords: hormone; perfluorooctanoic acid; corticosteroid binding; cbg ... See more keywords
Steroidogenic genes expressions are repressed by high levels of leptin and the JAK/STAT signaling pathway in MA-10 Leydig cells
Sign Up to like & getrecommendations! Published in 2017 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-017-3017-x
Abstract: The adipose tissue is an important endocrine organ secreting numerous peptide hormones, including leptin. Increased circulating levels of leptin, as a result of hormonal resistance in obese individuals, may contribute to lower androgen production in… read more here.
Keywords: levels leptin; high levels; stat signaling; jak stat ... See more keywords
Effects of Fluoride on Surface Structure of Primary Culture Leydig Cells in Mouse
Sign Up to like & getrecommendations! Published in 2017 at "Biological Trace Element Research"
DOI: 10.1007/s12011-017-1121-0
Abstract: Fluoride (F) is known to induce reproduction toxicity, and the elucidation of its underlying mechanisms is an ongoing research. These findings aim to provide deeper insights into roles of soduim fluoride (NaF) in testis damage,… read more here.
Keywords: effects fluoride; leydig; leydig cells; surface structure ... See more keywords
Bisphenol A disrupts steroidogenesis and induces a sex hormone imbalance through c-Jun phosphorylation in Leydig cells.
Sign Up to like & getrecommendations! Published in 2017 at "Chemosphere"
DOI: 10.1016/j.chemosphere.2017.07.004
Abstract: Bisphenol A (BPA) is a well-known endocrine disrupting chemical (EDC) that is used to manufacture plastic consumer products. It is well known that exposure to BPA can induce defects in gonad development and negatively influences… read more here.
Keywords: hormone; leydig cells; jun phosphorylation; sex hormone ... See more keywords
Cypermethrin triggers YY1-mediated testosterone biosynthesis suppression.
Sign Up to like & getrecommendations! Published in 2021 at "Ecotoxicology and environmental safety"
DOI: 10.1016/j.ecoenv.2021.112792
Abstract: Cypermethrin (CYP), an extensively-used broad-spectrum pyrethroid pesticide, is regarded as a potential environmental endocrine disruptor with the anti-androgenic characteristic. To explore underlying roles of non-coding RNAs and the Jak/Stat pathway in CYP-mediated testosterone biosynthesis suppression,… read more here.
Keywords: testosterone biosynthesis; mir 142; mediated testosterone; biosynthesis suppression ... See more keywords