Disruption of tp53 leads to cutaneous nevus and melanoma formation in Xenopus tropicalis
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13301
Abstract: In humans, germline TP53 mutations predispose carriers to a wide spectrum of cancers, which is known as Li–Fraumeni syndrome (LFS). To date, the association of melanomas with LFS remains unestablished. No melanomas have been reported… read more here.
Keywords: disruption; xenopus tropicalis; tp53; lfs ... See more keywords
The Evaluation of a Lateral Flow Strip Based on the Covalently Fixed “End-On” Orientation of an Antibody for Listeria monocytogenes Detection
Sign Up to like & getrecommendations! Published in 2024 at "Analytical Chemistry"
DOI: 10.1021/acs.analchem.4c00533
Abstract: In this study, the covalently fixed “end-on” orientation of a monoclonal Listeria monocytogenes antibody (mAb-Lis) to amino terminated oligo (ethylene glycol)-capped gold nanoparticles (NH2-TEG-AuNPs) was used to fabricate an in-house lateral flow strip (LFS), namely,… read more here.
Keywords: end; fixed end; lfs; teg aunps ... See more keywords
Pancreatic Cancer Risk and Screening Outcomes in Li-Fraumeni Syndrome.
Sign Up to like & getrecommendations! Published in 2025 at "Pancreas"
DOI: 10.1097/mpa.0000000000002483
Abstract: OBJECTIVES Li-Fraumeni syndrome (LFS) is a cancer predisposition syndrome that may confer increased pancreatic cancer (PC) risk. This study assesses PC risk and the rate of pancreatic imaging abnormalities in LFS. METHODS PC prevalence in… read more here.
Keywords: fraumeni syndrome; age; cancer; cancer risk ... See more keywords
Evidence for origin of Lavender Foal Syndrome among Egyptian Arabian horses in Egypt.
Sign Up to like & getrecommendations! Published in 2022 at "Equine veterinary journal"
DOI: 10.1111/evj.13604
Abstract: BACKGROUND Lavender Foal Syndrome (LFS) is a fatal hereditary condition that is inherited in an autosomal recessive pattern. This detrimental mutation is more common in Arabian foals of Egyptian origin than foals from other bloodlines.… read more here.
Keywords: horses egypt; lfs; foal syndrome; arabian horses ... See more keywords
Intensity-dependent modulation of cortical somatosensory processing during external, low-frequency peripheral nerve stimulation in humans
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neurophysiology"
DOI: 10.1152/jn.00511.2021
Abstract: External low-frequency peripheral nerve stimulation (LFS) has been proposed as a novel method for neuropathic pain relief. Previous studies have reported that LFS elicits long-term depression-like effects on human pain perception when delivered at noxious… read more here.
Keywords: low frequency; peripheral nerve; lfs; nerve ... See more keywords
Low Frequency Electrical Stimulation Either Prior to Or after Rapid Kindling Stimulation Inhibits the Kindling-Induced Epileptogenesis
Sign Up to like & getrecommendations! Published in 2017 at "BioMed Research International"
DOI: 10.1155/2017/8623743
Abstract: Objective. Studies are ongoing to find appropriate low frequency stimulation (LFS) protocol for treatment of epilepsy. The present study aimed at assessing the antiepileptogenesis effects of LFS with the same protocol applied either just before… read more here.
Keywords: stimulation; lfs; kindling stimulation; rapid kindling ... See more keywords
Abstract 3018: Transcriptional dysregulation in germline TP53-driven breast cancers
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-3018
Abstract: Background: Pathogenic germline variants (PGVs) in TP53 is associated with multicancer risk syndrome known as Li-Fraumeni Syndrome (LFS) and females have 80-90% risk of breast cancer at very early age compared to sporadic breast cancers.… read more here.
Keywords: cancer; breast; driven breast; lfs ... See more keywords
Abstract B019: Characterization of the extracellular vesicle proteome in Li-Fraumeni Syndrome
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.pediatric24-b019
Abstract: Li-Fraumeni Syndrome (LFS) is a hereditary cancer predisposition syndrome associated with germline mutations in the TP53 tumor suppressor gene. People with LFS are burdened with an increased lifetime risk to develop a broad spectrum of… read more here.
Keywords: fraumeni syndrome; characterization extracellular; cancer; lfs ... See more keywords
Beyond TP53: Molecular IPSS-genes multihit status revisited
Sign Up to like & getrecommendations! Published in 2025 at "Blood"
DOI: 10.1182/blood-2025-2090
Abstract: Introduction Molecular profiling has improved risk assessment in myelodysplastic syndromes (MDS), leading to the development of the Molecular International Prognostic Scoring System (IPSS-M). This model incorporates 31 genes but only considers multihit status (MS) for… read more here.
Keywords: multihit status; lfs; ipss genes; status ... See more keywords
Population-based assessment of leiomyosarcoma (LMS) and cancers in the Li-Fraumeni syndrome (LFS) spectrum: Implications for genetic testing criteria.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2025.43.16_suppl.11570
Abstract: 11570 Background: Data regarding the heritability of rare tumors is limited and may prevent incorporation into genetic testing criteria. This study utilized the Utah Population Database (UPDB) to evaluate cancer risks among LMS cases and… read more here.
Keywords: cancer; lfs; spectrum; uterine lms ... See more keywords
Complexity in interpreting cardiac valve-associated thrombus from tumors in Li-Fraumeni syndrome
Sign Up to like & getrecommendations! Published in 2024 at "World Journal of Clinical Cases"
DOI: 10.12998/wjcc.v12.i31.6431
Abstract: Li-Fraumeni syndrome (LFS) is a well-defined autosomal dominant predisposition syndrome due to TP53 germline mutation that causes many cancer malignancies. This early-onset syndrome poses a state of widespread malignancy. Such an inherited condition possessing defective… read more here.
Keywords: fraumeni syndrome; lfs; cardiac valve; valve associated ... See more keywords