p53 mutants G245S and R337H associated with the Li-Fraumeni syndrome regulate distinct metabolic pathways.
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DOI: 10.1016/j.biochi.2022.03.003
Abstract: Li-Fraumeni and Li-Fraumeni-like syndromes (LFS/LFL) are hereditary cancer predisposition disorders associated with germline mutations in the TP53 tumor suppressor gene. Here, we stably expressed LFS/LFL-associated p53 mutants R337H and G245S in p53-null H1299 cells to study… read more here.
Keywords: expression; p53 mutants; distinct metabolic; lfs lfl ... See more keywords