ADAM23 is a negative regulator of Kv1.1/Kv1.4 potassium currents
Sign Up to like & getrecommendations! Published in 2019 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2019.04.012
Abstract: Background ADAM22 and ADAM23 are transmembrane proteins that bind the secreted synaptic protein LGI1 and associate with Kv1.1/Kv1.4 potassium channels. However, the roles of these proteins in regulated voltage-gated potassium currents are poorly understood. Methods… read more here.
Keywords: kv1; kv1 kv1; kv1 currents; lgi1 ... See more keywords
Structural basis of epilepsy-related ligand–receptor complex LGI1–ADAM22
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DOI: 10.1038/s41467-018-03947-w
Abstract: Epilepsy is a common brain disorder throughout history. Epilepsy-related ligand–receptor complex, LGI1–ADAM22, regulates synaptic transmission and has emerged as a determinant of brain excitability, as their mutations and acquired LGI1 autoantibodies cause epileptic disorders in… read more here.
Keywords: receptor; lgi1; epilepsy related; lgi1 adam22 ... See more keywords
A role for leucine-rich, glioma inactivated 1 in regulating pain sensitivity
Sign Up to like & getrecommendations! Published in 2024 at "Brain"
DOI: 10.1093/brain/awae302
Abstract: Abstract Neuronal hyperexcitability is a key driver of persistent pain states, including neuropathic pain. Leucine-rich, glioma inactivated 1 (LGI1) is a secreted protein known to regulate excitability within the nervous system and is the target… read more here.
Keywords: mice; role; pain; leucine rich ... See more keywords
Novel risk loci in LGI1-antibody encephalitis: genome-wide association study discovery and validation cohorts
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DOI: 10.1093/brain/awae349
Abstract: Abstract Encephalitis with antibodies to leucine-rich glioma-inactivated 1 (LGI1-Ab-E) is a common form of autoimmune encephalitis, presenting with seizures and neuropsychiatric changes, predominantly in older males. More than 90% of patients carry the human leukocyte… read more here.
Keywords: hla; genome wide; lgi1; association study ... See more keywords
LGI1 antibodies alter Kv1.1 and AMPA receptors changing synaptic excitability, plasticity and memory
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DOI: 10.1093/brain/awy253
Abstract: Leucine-rich glioma-inactivated 1 (LGI1) is a secreted neuronal protein that forms a trans-synaptic complex that includes the presynaptic disintegrin and metalloproteinase domain-containing protein 23 (ADAM23), which interacts with voltage-gated potassium channels Kv1.1, and the postsynaptic… read more here.
Keywords: kv1 ampa; ampa receptors; lgi1; plasticity ... See more keywords
Structural insights into heterohexameric assembly of epilepsy-related ligand–receptor complex LGI1–ADAM22
Sign Up to like & getrecommendations! Published in 2025 at "eLife"
DOI: 10.1101/2025.01.06.631603
Abstract: Leucine-rich glioma-inactivated 1 protein (LGI1) is a secreted neuronal protein consisting of the N-terminal leucine-rich repeat (LRR) and C-terminal epitempin repeat (EPTP) domains. LGI1 is linked to epilepsy, a neurological disorder that can be caused… read more here.
Keywords: receptor; ligand; adam22 complex; lgi1 adam22 ... See more keywords
Morvan syndrome associated with LGI1 antibody: a case report
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DOI: 10.1186/s12883-021-02205-9
Abstract: Background Morvan syndrome (MoS) is a rare autoimmune syndrome associated with antibodies against two kinds of potassium channel proteins, contactin associated protein-like 2 (CASPR2) and leucine-rich glioma inactivated protein 1 (LGI1). MoS patients with only… read more here.
Keywords: syndrome associated; morvan syndrome; lgi1 antibody; lgi1 ... See more keywords
Autoimmune encephalitis with coexistent LGI1 and GABABR1 antibodies: case report
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DOI: 10.1186/s12883-021-02460-w
Abstract: Background Autoimmune encephalitis (AE) with multiple auto-antibodies is of great clinical significance because its complex clinical manifestations and atypical imaging increase the difficulty of diagnosis, differential diagnosis and treatment, which may aggravate the disease, increase… read more here.
Keywords: lgi1; autoimmune encephalitis; report; case ... See more keywords
ADAM22 and ADAM23 modulate the targeting of the Kv1 channel-associated protein LGI1 to the axon initial segment
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cell Science"
DOI: 10.1242/jcs.219774
Abstract: ABSTRACT The distribution of the voltage-gated Kv1 K+ channels at the axon initial segment (AIS) influences neuronal intrinsic excitability. The Kv1.1 and Kv1.2 (also known as KCNA1 and KCNA2, respectively) subunits are associated with cell… read more here.
Keywords: initial segment; axon initial; adam23 modulate; lgi1 ... See more keywords