Distinct HLA associations of LGI1 and CASPR2-antibody diseases
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DOI: 10.1093/brain/awy109
Abstract: The mechanisms responsible for the generation of LGI1- or CASPR2-antibodies are unknown. Binks et al. describe two strikingly dichotomous HLA-associations, most significantly in HLA-DRB1*07:01 for LGI1, and HLA-DRB1*11:01 for CASPR2. Prediction of antigen-specific HLA-binding peptides… read more here.
Keywords: distinct hla; lgi1 caspr2; associations lgi1; hla ... See more keywords
Seizure underreporting in LGI1 and CASPR2 antibody encephalitis
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DOI: 10.1111/epi.17338
Abstract: Patients with anti‐leucine‐rich glioma‐inactivated 1 protein (LGI1) or anti‐contactin‐associated protein 2 (CASPR2) antibody encephalitis typically present with frequent epileptic seizures. The seizures generally respond well to immunosuppressive therapy, and the long‐term seizure outcome seems to… read more here.
Keywords: seizure; caspr2 antibody; antibody encephalitis; lgi1 caspr2 ... See more keywords