Clonal expansion of large granular lymphocytes in patients with spondyloarthritis and psoriatic arthritis treated with TNFα inhibitors
Sign Up to like & getrecommendations! Published in 2021 at "Rheumatology International"
DOI: 10.1007/s00296-021-04872-w
Abstract: To determine the prevalence of clonal T-large granular lymphocyte (T-LGL) cells in patients with spondyloarthritis (SpA) and psoriatic arthritis (PsA) and to define possible risk factors for this condition. We present a cross-sectional analysis with… read more here.
Keywords: psoriatic arthritis; patients spondyloarthritis; lgl; large granular ... See more keywords
PP1-Mediated Dephosphorylation of Lgl Controls Apical-basal Polarity.
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2018.12.060
Abstract: Apical-basal polarity is a common trait that underlies epithelial function. Although the asymmetric distribution of cortical polarity proteins works in a functioning equilibrium, it also retains plasticity to accommodate cell division, during which the basolateral… read more here.
Keywords: apical basal; basal polarity; pp1; lgl ... See more keywords
Novel invariant features of Good syndrome
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DOI: 10.1038/s41375-020-01114-z
Abstract: Good syndrome (GS), originally described in 1954 by Dr Robert Good in a series of three patients, classically comprises hypogammaglobulinemia (HG) and thymoma [1]. We encountered a challenging 85-year-old patient with 5 months duration of… read more here.
Keywords: prca lgl; good syndrome; lgl; novel invariant ... See more keywords
miR-181a is a novel player in the STAT3-mediated survival network of TCRαβ+ CD8+ T large granular lymphocyte leukemia
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DOI: 10.1038/s41375-021-01480-2
Abstract: T-LGL cells arise as a consequence of chronic antigenic stimulation and inflammation and thrive because of constitutive activation of the STAT3 and ERK pathway. Notably, in 40% of patients, constitutive STAT3 activation is due to… read more here.
Keywords: inhibition; cd8; leukemia; lgl ... See more keywords
Choroidal Infiltration as First Clinical Manifestation of T-cell Large Granular Lymphocyte (T-LGL) Leukemia
Sign Up to like & getrecommendations! Published in 2019 at "Ocular Immunology and Inflammation"
DOI: 10.1080/09273948.2019.1645186
Abstract: ABSTRACT Purpose: To report of a 55-year-old woman suffering from choroidal infiltrates as a first clinical manifestation of T-LGL leukemia. Methods: Retrospective case report. Results: A healthy woman presented with photophobia in both eyes since… read more here.
Keywords: choroidal; first clinical; clinical manifestation; lgl ... See more keywords
Prevalence and significance of large granular lymphocytes in patients with immune thrombocytopenia.
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DOI: 10.1080/09537104.2022.2144194
Abstract: The association between T-cell large granular lymphocytes (T-LGL) and ITP is uncertain. The aims of this study were to determine the prevalence of T-LGL in patients with ITP and to describe its association with ITP… read more here.
Keywords: patients itp; itp patients; itp; lgl ... See more keywords
Subclinical Large Granular Lymphocyte Clone in Myelodysplastic Syndrome: A Case Report and Literature Review
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DOI: 10.1182/blood-2024-201908
Abstract: Introduction Large Granular Lymphocyte (LGL) clones are common in patients with MDS. They may be subclinical and revealed by identifying a STAT3 mutation. LGL leukemia arises from the clonal proliferation of LGLs, most commonly T-cells… read more here.
Keywords: clone; lgl clones; mds; ist ... See more keywords
Low-Count T-/NK-Large Granular Lymphocytic Leukemia: A Nosologically Distinct Disease Subtype at the Crossroads between Lymphoproliferation, Autoimmunity and Immunodeficiency
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DOI: 10.1182/blood-2024-209437
Abstract: Classical diagnosis of large granular lymphocytic leukemia (LGLL) relies on increased blood LGLs ≥2x109/L in analogy to other low grade leukemias/lymphomas. However, despite fulfilling standard criteria, the disease does not often present with hyperleukocytosis but… read more here.
Keywords: disease; lgll; subtype; count ... See more keywords
Bone marrow CD57+ LGL cells comprised of NK and CD8 T cells drive bone marrow failure in Myelodysplastic Syndromes
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DOI: 10.1182/blood-2025-5619
Abstract: Background: Autoimmune phenomena occur in 20-50% of patients with myelodysplastic syndromes (MDS), exacerbating hematopoietic suppression and increasing cardiovascular/infection/bleeding risks. Recent data from our group suggest that the canonical model of stem cell intrinsic failure in… read more here.
Keywords: cd8 cells; mds patients; seq; lgl ... See more keywords
A modern view of LGL leukemia.
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DOI: 10.1182/blood.2023021790
Abstract: Large granular lymphocytic (LGL) leukemia is a rare lymphoproliferative chronic disorder characterized by expansion of either T- or NK- cytotoxic cells. Contrary to EBV-induced aggressive NK-LGL leukemia, chronic T- and NK-LGL leukemia are indolent diseases… read more here.
Keywords: modern view; lgl leukemia; lgl; view lgl ... See more keywords
Successful treatment of cerebral aspergillosis: case report of a patient with T-cell large granular lymphocytic leukemia (T-LGL)
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DOI: 10.1186/s12879-017-2877-8
Abstract: BackgroundInvasive aspergillosis involving patients with neutropenia or severe immunosuppression, such as patients with hematologic malignancies is associated with high mortality. Patients with T-cell large granular lymphocytic leukemia (T-LGL) on the other hand are considered to… read more here.
Keywords: aspergillosis; lgl; infection; treatment ... See more keywords